{"id":"W2395213522","doi":"10.1016/b978-0-12-374279-7.04011-x","title":"TCR Affinity and Signaling during Thymocyte Selection","year":2016,"lang":"en","type":"book-chapter","venue":"Elsevier eBooks","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Thymocyte; T-cell receptor; Negative selection; Biology; Major histocompatibility complex; Cell biology; Selection (genetic algorithm); Programmed cell death; Agonist; Positive selection; Receptor; T cell; Immunology; Antigen; Genetics; Immune system; Apoptosis; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521496,0.0003734434,0.0001595459,0.0002522524,0.0002178394,0.001283333,0.0003861753,0.0004396809,0.006088001],"category_scores_gemma":[0.0001221724,0.0002128739,0.0001037991,0.0002560172,0.000295046,0.0007587763,0.0003847035,0.0008355674,0.002999912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004805159,"about_ca_system_score_gemma":0.0002111738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003699961,"about_ca_topic_score_gemma":0.0007732802,"domain_scores_codex":[0.9998986,0.0000104715,0.000004713567,0.00001880044,0.00004875858,0.00001858913],"domain_scores_gemma":[0.9999679,0.00001275852,0.000004154747,0.000002512977,0.000005507648,0.000007162286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002756553,0.00004429225,0.0005824835,0.0002267079,0.00000920592,0.0004378669,0.0002203751,0.0007720485,0.6461686,0.04089656,0.007369664,0.3029965],"study_design_scores_gemma":[0.00002634973,0.0002242645,0.01029313,0.0003078991,0.00004093944,0.002162991,0.0004065832,0.004682664,0.3486705,0.05219361,0.580942,0.0000490805],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1599053,0.1722433,0.05300279,0.001989345,0.002118857,0.00003374509,0.0003399714,0.0005840855,0.6097826],"genre_scores_gemma":[0.4938167,0.05667102,0.009060767,0.000657765,0.000648014,0.00004256336,0.0003223465,0.0002509111,0.4385299],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006088001,"threshold_uncertainty_score":0.02036637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107317084812464,"score_gpt":0.2110085477457895,"score_spread":0.1999353768976648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}