{"id":"W2395217429","doi":"10.1038/cddis.2015.293","title":"Heart disease: recruitment of MEF2 activity by β−blockers wards off cardiomyocyte death","year":2015,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada); York University","funders":"","keywords":"Mef2; Heart failure; Programmed cell death; Myocyte; Myocardial infarction; Apoptosis; Medicine; Disease; Ventricular remodeling; Internal medicine; Heart disease; Cardiac function curve; Regeneration (biology); Biology; Cardiology; Cell biology; Transcription factor; Gene; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001974016,0.0002123525,0.0004501047,0.00006348823,0.0000656454,0.00002166291,0.000047686,0.00006027752,0.00001088474],"category_scores_gemma":[0.00008729743,0.0001709601,0.0002867666,0.00008462,0.00007118585,0.00007518717,0.0000729607,0.0001028662,0.00001040551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009149969,"about_ca_system_score_gemma":0.0004969392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008504363,"about_ca_topic_score_gemma":2.604917e-7,"domain_scores_codex":[0.9986363,0.00006160546,0.0001988475,0.000376231,0.0004345583,0.0002924275],"domain_scores_gemma":[0.9969571,0.00002398662,0.00005907563,0.0004215712,0.0001194917,0.002418775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01584434,0.002688791,0.769353,0.002691198,0.0004816449,0.0002680238,0.0006172542,0.0005789879,0.02806158,0.0003184522,0.1564562,0.02264058],"study_design_scores_gemma":[0.01543426,0.0008829136,0.59794,0.0007738626,0.005116795,0.00003126072,0.0004117607,0.01305265,0.01262683,0.00109567,0.3511735,0.001460567],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685034,0.02703416,0.0001485296,0.001123381,0.0001924535,0.0007188792,0.0002538775,0.00005079516,0.001974553],"genre_scores_gemma":[0.9974517,0.000552434,0.0002591514,0.0003583811,0.0001421951,0.00004092704,0.00009287486,0.00002716152,0.001075237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1947173,"threshold_uncertainty_score":0.6971549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05153694723573535,"score_gpt":0.2989218122399547,"score_spread":0.2473848650042193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}