{"id":"W2395316927","doi":"10.1177/1352458516649037","title":"Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study","year":2016,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; NeuroRx Research (Canada)","funders":"National Institute for Health and Care Research; Biogen","keywords":"Glatiramer acetate; Dimethyl fumarate; Medicine; Adverse effect; Multiple sclerosis; Relapsing remitting; Randomized controlled trial; Interim analysis; Placebo; Discontinuation; Internal medicine; Magnetic resonance imaging; Psychiatry; Radiology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001378075,0.0004277796,0.002372826,0.001606048,0.0001310876,0.00003124359,0.0002771259,0.0002022065,0.0001856262],"category_scores_gemma":[0.002860254,0.0002541039,0.001339899,0.001237478,0.0003542253,0.0002556852,0.0001470073,0.0004053103,0.00001375696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157486,"about_ca_system_score_gemma":0.0001357802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006128121,"about_ca_topic_score_gemma":0.0003033808,"domain_scores_codex":[0.9955761,0.0008091331,0.001808491,0.0005037381,0.000751176,0.0005513703],"domain_scores_gemma":[0.9954646,0.001952987,0.001035203,0.000618201,0.0004131697,0.0005158318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05272872,0.004152324,0.494532,0.00008870211,0.004470373,0.0001311558,0.0006090967,0.0001450167,0.4284701,0.000001005987,0.00002950879,0.01464193],"study_design_scores_gemma":[0.2036392,0.0008262743,0.7407928,0.002800322,0.006059977,0.00001488539,0.0001299435,0.002122744,0.04337952,0.00000622808,6.721217e-7,0.0002274196],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925776,0.004345915,0.001116851,0.00005841144,0.0003520846,0.001444479,0.00005672669,0.00003602831,0.00001190535],"genre_scores_gemma":[0.9964525,0.002960856,0.000254028,0.00005452927,0.00007421479,0.00008055142,0.0000119073,0.00005141534,0.00006005623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3850906,"threshold_uncertainty_score":0.9999911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05278964814425009,"score_gpt":0.2852498998176108,"score_spread":0.2324602516733608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}