{"id":"W2395533450","doi":"10.1158/1557-3125.advbc15-b45","title":"Abstract B45: De novo generation of highly aggressive human breast tumors by rapid serial passaging of oncogene-transduced starting populations of purified normal cells","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Biology; Cancer research; MUC1; Matrigel; Carcinogenesis; In vivo; Progenitor cell; Syngenic; Xenotransplantation; CD44; Cell culture; Cancer; Cell; Pathology; Transplantation; Immunology; Stem cell; Angiogenesis; Antigen; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008301558,0.0001454527,0.0004026674,0.000261433,0.00009260976,0.00001102757,0.0001516472,0.00008626113,0.0004770896],"category_scores_gemma":[0.00005271407,0.0001197846,0.0001608453,0.0003260349,0.0001991136,0.00008255577,0.00004706923,0.0001862107,0.000001600696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002186895,"about_ca_system_score_gemma":0.0006045547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003682117,"about_ca_topic_score_gemma":0.0003642378,"domain_scores_codex":[0.9976155,0.0001721421,0.0006154453,0.0002993863,0.0008455966,0.0004519332],"domain_scores_gemma":[0.9984375,0.00004403055,0.0003699551,0.0003517841,0.0006276811,0.0001690685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003931024,0.0001523434,0.001311932,0.0002907121,0.0001100771,0.00003931322,0.0002934516,0.0001849876,0.9809986,0.00005781996,0.0004372801,0.01573037],"study_design_scores_gemma":[0.002101913,0.0002151421,0.002496237,0.0004908607,0.00007236777,0.000007896218,0.00007343351,0.00001860821,0.9942612,0.00002754802,0.0001257897,0.0001089941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963458,0.000920799,0.0008329203,0.0005930743,0.0000880916,0.000462628,0.0004605744,0.000009856263,0.000286313],"genre_scores_gemma":[0.9988546,0.0001719839,0.0005221532,0.00002497075,0.0001696475,0.00005293778,0.00005469858,0.00003814111,0.0001108068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01562138,"threshold_uncertainty_score":0.5566284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08656448618080148,"score_gpt":0.3838695273847533,"score_spread":0.2973050412039518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}