{"id":"W2395533450","doi":"10.1158/1557-3125.advbc15-b45","title":"Abstract B45: De novo generation of highly aggressive human breast tumors by rapid serial passaging of oncogene-transduced starting populations of purified normal cells","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute","funders":"","keywords":"Biology; Cancer research; MUC1; Matrigel; Carcinogenesis; In vivo; Progenitor cell; Syngenic; Xenotransplantation; CD44; Cell culture; Cancer; Cell; Pathology; Transplantation; Immunology; Stem cell; Angiogenesis; Antigen; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002482942,0.0003454977,0.0002769346,0.0002778738,0.0001552069,0.0003809428,0.0002394523,0.0002602356,0.001581953],"category_scores_gemma":[0.0001073704,0.0001668402,0.0002586737,0.0001460668,0.0001225541,0.0001225802,0.0002562817,0.0006502641,0.001136863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001685926,"about_ca_system_score_gemma":0.000156509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008813702,"about_ca_topic_score_gemma":0.0008559908,"domain_scores_codex":[0.9998121,0.0000219894,0.00001930398,0.00004799328,0.00006085114,0.00003779471],"domain_scores_gemma":[0.9998807,0.00002027003,0.00001530846,0.00002994471,0.00001686468,0.00003703642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000397964,0.00004282245,0.000136511,0.00001337376,0.000004160141,0.00003001713,0.00002168754,0.00006277186,0.9977374,0.0001777372,0.0001326275,0.001601017],"study_design_scores_gemma":[0.00002429754,0.0003904261,0.002648664,0.000006606983,0.00002148811,0.0003317252,0.00001214788,0.00180784,0.9858213,0.00006313613,0.008866237,0.000005975382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562473,0.001702632,0.03120018,0.0002041537,0.0001052588,0.0004767947,0.002768096,0.0006526685,0.006642987],"genre_scores_gemma":[0.9569896,0.001082336,0.02554924,0.0001263372,0.00002883032,0.0002038136,0.004248737,0.0001752512,0.01159572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581953,"threshold_uncertainty_score":0.005292177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08656448618080148,"score_gpt":0.3838695273847533,"score_spread":0.2973050412039518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}