{"id":"W2395554454","doi":"10.1038/nchembio.2085","title":"An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":357,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Genentech; Howard Hughes Medical Institute","keywords":"H3K4me3; Cancer cell; Cancer research; Histone; Cancer; Biology; Chemistry; Cell biology; Biochemistry; Genetics; Gene expression; Gene; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417279,0.0002927132,0.0004768833,0.0002512017,0.0001996431,0.0003386171,0.000442338,0.0003482015,0.00292411],"category_scores_gemma":[0.0001852279,0.0001651272,0.0002561405,0.0002609096,0.0002105548,0.0001863944,0.000206352,0.0007037069,0.0004452626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004211138,"about_ca_system_score_gemma":0.0003547392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001703441,"about_ca_topic_score_gemma":0.002962144,"domain_scores_codex":[0.9998363,0.00002054674,0.00001823092,0.00002880857,0.00003984225,0.00005625999],"domain_scores_gemma":[0.9998617,0.00003339777,0.00002504488,0.00002418205,0.00001447692,0.00004122289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007653249,0.0002063825,0.0004560796,0.00006604135,0.00003633243,0.00005425098,0.00002489841,0.0003693715,0.9916517,0.0002584847,0.0004493236,0.005661817],"study_design_scores_gemma":[0.00004638362,0.0009035631,0.003155564,0.000005051109,0.00002671558,0.0001219234,0.00003540079,0.001147761,0.9915702,0.00004350944,0.002937506,0.000006506581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940206,0.001370431,0.00140495,0.0001993645,0.00008198405,0.00002800631,0.0004956451,0.0001840854,0.002214928],"genre_scores_gemma":[0.9955783,0.0005495712,0.0007169147,0.00006251774,0.000007970008,0.00002065542,0.0006396013,0.00001929199,0.002405133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292411,"threshold_uncertainty_score":0.009782135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007624833346380898,"score_gpt":0.2922059899745503,"score_spread":0.2845811566281694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}