{"id":"W2395836636","doi":"10.1371/journal.pone.0156347","title":"The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Livestock and Meat Agency; Manitoba Medical Service Foundation; Research Manitoba","keywords":"Quinine; Agonist; Internalization; Taste receptor; Taste; Pharmacology; Receptor; Mechanism of action; Chemistry; Signal transduction; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164728,0.00009237448,0.0001874455,0.00003357348,0.00007035214,0.000009777615,0.000122614,0.00005423307,0.00009672384],"category_scores_gemma":[0.00009718212,0.00004554238,0.0000701724,0.00009904675,0.0001250495,0.00003865001,0.00003389303,0.0000980645,0.00003395536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003037418,"about_ca_system_score_gemma":0.000002644199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001371837,"about_ca_topic_score_gemma":0.000002443358,"domain_scores_codex":[0.999207,0.000069218,0.0001488066,0.0001611763,0.0002549512,0.0001589144],"domain_scores_gemma":[0.9993134,0.0002220456,0.00009810663,0.0002610696,0.0000650728,0.00004035768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002638312,0.0004670678,0.0002331803,0.000009496905,0.000102343,1.885145e-7,0.00002542819,1.455085e-8,0.9627973,0.00002638877,0.003310007,0.03276478],"study_design_scores_gemma":[0.0001870849,0.0001737342,0.000202087,0.000193541,0.00008719657,1.378149e-7,0.000002520571,0.00004925085,0.9978289,0.0002003521,0.0009993223,0.00007588138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786398,0.00004221588,0.00003812966,0.02020035,0.00005575095,0.00006311999,0.000005388473,0.00008088988,0.0008743273],"genre_scores_gemma":[0.9981095,0.0000682037,0.0005741708,0.0003308184,0.0001258342,0.000004090321,9.874353e-7,0.00001396384,0.0007723857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03503162,"threshold_uncertainty_score":0.1857165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04489027380494622,"score_gpt":0.2595193591214164,"score_spread":0.2146290853164702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}