{"id":"W2395881780","doi":"10.1159/000457103","title":"Hydroxylation and Glucuronidation of Various Xenobiotics by Hepatic Microsomes from the Fetal Lamb, Pregnant Ewe and Human Fetus","year":2017,"lang":"en","type":"article","venue":"Developmental Pharmacology and Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute on Drug Abuse","keywords":"Microsome; Glucuronidation; Hexobarbital; Fetus; Hydroxylation; Chemistry; Cytochrome; Biotransformation; Microsoma; Drug metabolism; Internal medicine; Xenobiotic; Endocrinology; Cytochrome P450; Pharmacology; Metabolism; Biochemistry; Biology; Pregnancy; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0004946978,0.000316536,0.0003546914,0.00005276629,0.001427672,0.00008003046,0.0003214419,0.0002855664,0.0001451576],"category_scores_gemma":[0.00001403001,0.0002604934,0.00003756064,0.00005067363,0.001088667,0.0001350699,0.0003370075,0.000496073,0.000006988885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003116206,"about_ca_system_score_gemma":0.00006654825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009038662,"about_ca_topic_score_gemma":0.00003985443,"domain_scores_codex":[0.9983419,0.0003210485,0.0004376535,0.0003958581,0.0001361481,0.0003674626],"domain_scores_gemma":[0.9988775,0.0003494163,0.0003902402,0.000163595,0.00006236508,0.0001568884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002353833,0.0002778042,0.1339264,0.00004986743,0.0008437803,0.00001002309,0.002721111,0.000006110214,0.8122941,0.0004181091,0.0005398465,0.04867755],"study_design_scores_gemma":[0.007899689,0.0001865121,0.1977559,0.0000445093,0.001558416,0.00006750153,0.0003251052,0.003190128,0.6827062,0.003357674,0.1021788,0.0007295577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869323,0.009703415,0.00004366068,0.001286513,0.0007930676,0.0005192504,0.0002310992,0.00002668874,0.0004639402],"genre_scores_gemma":[0.9883542,0.00853135,0.000314243,0.002270437,0.0001347097,0.00002332153,0.00008334088,0.00002852031,0.0002598766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1295879,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05451451887463708,"score_gpt":0.3804349613715216,"score_spread":0.3259204424968845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}