{"id":"W2396023791","doi":"10.4049/jimmunol.1501264","title":"LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Central University of Jharkhand","keywords":"Notch signaling pathway; ICAM-1; Cell biology; Polarization (electrochemistry); Signal transduction; Ligation; Hes3 signaling axis; Chemistry; Biology; Molecular biology; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007553456,0.0002258709,0.0001478579,0.000122713,0.0001164755,0.0002800828,0.00005188295,0.0001438863,0.002397518],"category_scores_gemma":[0.00006702427,0.0000693807,0.0002287645,0.0000855401,0.00007127885,0.00008660447,0.0001400158,0.0003313326,0.0005229062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181737,"about_ca_system_score_gemma":0.0001223728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002598495,"about_ca_topic_score_gemma":0.0003541384,"domain_scores_codex":[0.9999059,0.00002482613,0.0000079552,0.00001649971,0.00001483794,0.00002995066],"domain_scores_gemma":[0.9999733,0.000005290377,0.000008606174,0.000003512203,0.000003567607,0.000005707603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000242519,0.00004430993,0.0008202394,0.00008060705,0.00001166979,0.0001633785,0.0000267916,0.00007555812,0.9948063,0.0000598295,0.0001298901,0.003538932],"study_design_scores_gemma":[0.00008270518,0.0006162685,0.01980595,0.00002482647,0.00006002327,0.001014697,0.00009249098,0.001191573,0.9699224,0.0001187535,0.007062973,0.000007410849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992708,0.00324616,0.001204843,0.0001647694,0.00004042962,0.00002602805,0.0002753168,0.0000476108,0.002286779],"genre_scores_gemma":[0.9965118,0.001207585,0.0007231629,0.00008297138,0.00002207477,0.0000271398,0.0003616946,0.000005174004,0.001058438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002397518,"threshold_uncertainty_score":0.008020461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276645292477786,"score_gpt":0.294163713773516,"score_spread":0.2713972608487381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}