{"id":"W2396078839","doi":"10.1038/nrclinonc.2016.64","title":"Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect","year":2016,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":205,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Pharmacokinetics; Chemotherapy; Oncology; Clinical trial; Pharmacology; Drug; Colorectal cancer; Intensive care medicine; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001008409,0.000539146,0.001817813,0.0006776678,0.000151496,0.001406811,0.0007289314,0.0009588261,0.002116682],"category_scores_gemma":[0.00188593,0.0002433816,0.0004383145,0.000935701,0.0006177821,0.001717076,0.0005516778,0.00235423,0.0009151371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007287807,"about_ca_system_score_gemma":0.001420026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007215377,"about_ca_topic_score_gemma":0.00149395,"domain_scores_codex":[0.9996212,0.0001231872,0.00004960238,0.00006269479,0.00011901,0.00002427685],"domain_scores_gemma":[0.9989488,0.0006248706,0.0001635577,0.00003572209,0.0001845785,0.00004256567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002277352,0.00005893528,0.0003834409,0.009490258,0.000119729,0.0001607797,0.00005268013,0.0006041382,0.003520027,0.00579451,0.02212662,0.9574612],"study_design_scores_gemma":[0.00006905563,0.0003721045,0.002010611,0.005033743,0.000338565,0.002765121,0.00008428642,0.0006488634,0.003022926,0.006737875,0.9788706,0.00004621009],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002633699,0.996802,0.0005089056,0.001424463,0.0001962895,0.000002961586,0.0000204617,0.00000962728,0.0007718618],"genre_scores_gemma":[0.004090187,0.9935256,0.0004698046,0.0007964969,0.0005193106,0.000007201173,0.00003494431,0.000005825145,0.0005506114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002116682,"threshold_uncertainty_score":0.007080972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1640822111862569,"score_gpt":0.5620383089072559,"score_spread":0.397956097720999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}