{"id":"W2396139000","doi":"10.1042/bcj20160087","title":"Domains of STIP1 responsible for regulating PrPC-dependent amyloid-β oligomer toxicity","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Phosphoprotein; Programmed cell death; Binding site; Oligomer; Plasma protein binding; Cell biology; Peptide; Biology; Hsp90; Hsp70; Molecular biology; Biochemistry; Chemistry; Heat shock protein; Apoptosis; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006921755,0.0003824661,0.0002604801,0.000139984,0.0001921504,0.000290904,0.0002900759,0.0003221735,0.00223374],"category_scores_gemma":[0.0001498937,0.0001318352,0.0002759226,0.000113142,0.0002314063,0.000146701,0.000218986,0.0004570207,0.001574617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003165265,"about_ca_system_score_gemma":0.0001496104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003046333,"about_ca_topic_score_gemma":0.0003116255,"domain_scores_codex":[0.9999384,0.000007986474,0.000005276643,0.00001517325,0.00001870096,0.00001453916],"domain_scores_gemma":[0.9998984,0.00001306605,0.00003629132,0.000008033194,0.000007990589,0.00003626071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001839137,0.00003368501,0.000521324,0.00006385833,0.000007589394,0.0002725479,0.00001811122,0.0002942592,0.996024,0.0002113716,0.000118688,0.002250572],"study_design_scores_gemma":[0.00006250118,0.0003225551,0.02654119,0.00002114155,0.00003556262,0.002610689,0.00007151051,0.006609025,0.9559314,0.0003246806,0.007444122,0.00002565494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931883,0.001706843,0.002937945,0.00008586069,0.00002384356,0.00004255758,0.0005474775,0.0001175377,0.00134971],"genre_scores_gemma":[0.9955072,0.0005241462,0.00161553,0.00005945771,0.00001184588,0.00002358802,0.0008401198,0.00002575247,0.001392398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00223374,"threshold_uncertainty_score":0.007472634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289333906880092,"score_gpt":0.2739638347714105,"score_spread":0.2610704957026095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}