{"id":"W2396152701","doi":"10.1158/1557-3265.ovca15-ia06","title":"Abstract IA06: Regulation of BRCA1- and BRCA2-dependent DNA repair.","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Olaparib; PALB2; Synthetic lethality; DNA repair; Cancer research; PARP inhibitor; Homologous recombination; Ovarian cancer; Cancer; DNA damage; Poly ADP ribose polymerase; BRCA2 Protein; Medicine; Biology; Polymerase; Mutation; DNA; Genetics; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000329142,0.001030843,0.0003978899,0.0008538415,0.0005244996,0.001586223,0.0007882918,0.0007020721,0.006864133],"category_scores_gemma":[0.0001914008,0.0002704374,0.0005726631,0.0005214479,0.0004227768,0.0004615234,0.0005895731,0.001345957,0.004271543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001073308,"about_ca_system_score_gemma":0.000504377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120638,"about_ca_topic_score_gemma":0.0008934997,"domain_scores_codex":[0.999775,0.00003484862,0.00001641383,0.00006978062,0.00006636198,0.0000375511],"domain_scores_gemma":[0.999828,0.00001699406,0.0000473148,0.00001363103,0.000044034,0.00005003773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006717514,0.00021974,0.0007018028,0.0007725435,0.00002674096,0.0004834422,0.000066624,0.0005482199,0.8849223,0.006742902,0.03515549,0.06968848],"study_design_scores_gemma":[0.0001136464,0.000802776,0.01321856,0.0002242598,0.00005583572,0.002032322,0.0001256716,0.002533667,0.6899858,0.002317786,0.2885505,0.0000391195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.306906,0.3471449,0.05209019,0.01373922,0.01491302,0.0008976001,0.0244128,0.00787074,0.2320255],"genre_scores_gemma":[0.6117243,0.1030406,0.0266744,0.003988507,0.001814254,0.0005853996,0.02983209,0.0005262728,0.2218142],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006864133,"threshold_uncertainty_score":0.02296281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.291583553690724,"score_gpt":0.5529012675953581,"score_spread":0.2613177139046341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}