{"id":"W2396230427","doi":"10.1126/science.aag0832","title":"The cancer predisposition revolution","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773334,0.00003081642,0.00001954326,0.000008260366,0.0002079658,0.00002745867,0.0002080677,0.00001575148,0.00000611723],"category_scores_gemma":[0.0001815739,0.0000157132,0.00001574607,0.00006970344,0.0002825961,0.000003011628,0.00007049396,0.00001034025,0.000009914653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003206028,"about_ca_system_score_gemma":0.0001499302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001024969,"about_ca_topic_score_gemma":0.00006823891,"domain_scores_codex":[0.9995445,0.0000067056,0.00005874107,0.000164375,0.00009780034,0.0001278531],"domain_scores_gemma":[0.999631,0.00001232302,0.00002847006,0.0002189553,0.00007569797,0.00003351233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009117352,0.000002724499,0.001995299,3.703164e-7,0.000001029008,6.493458e-8,0.000004352537,0.000005941297,0.9679169,0.0008186071,0.002645436,0.02660016],"study_design_scores_gemma":[0.0001737715,0.00008655892,0.07259803,0.00001307384,0.000003532268,0.00000281437,0.00001121307,0.00004481764,0.6500497,0.001063593,0.2758651,0.00008776549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989333,0.00162529,0.004384791,0.002545152,0.0006799272,0.0000875301,0.00002382798,0.000004703752,0.001315749],"genre_scores_gemma":[0.9974176,0.001470055,0.00008923734,0.0001355219,0.0001995839,0.00001445641,9.683785e-7,0.000002387551,0.000670246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3178672,"threshold_uncertainty_score":0.1599526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00535375967025604,"score_gpt":0.2528541680248772,"score_spread":0.2475004083546212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}