{"id":"W2396230427","doi":"10.1126/science.aag0832","title":"The cancer predisposition revolution","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006832515,0.0005299594,0.0009769826,0.0009308499,0.002000568,0.003329664,0.0006885103,0.004386764,0.007550052],"category_scores_gemma":[0.01229523,0.0003112906,0.0004217594,0.0006592391,0.01250526,0.005887077,0.00254018,0.00938111,0.00131133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004430117,"about_ca_system_score_gemma":0.003745136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003972339,"about_ca_topic_score_gemma":0.002839562,"domain_scores_codex":[0.9981474,0.0008112825,0.00004762127,0.00030443,0.000374461,0.0003149077],"domain_scores_gemma":[0.9942433,0.003437599,0.0002447836,0.0004490599,0.0006547552,0.0009705009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002444018,0.00009622484,0.002264925,0.0003146542,0.00007630967,0.0008145418,0.001954408,0.0004092015,0.001385678,0.8123698,0.1134933,0.06657658],"study_design_scores_gemma":[0.00005971023,0.00005240218,0.001744987,0.0003642427,0.00003510933,0.000639369,0.001131702,0.0001391909,0.0006246468,0.3312844,0.6638823,0.00004190575],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01990658,0.2597431,0.003020284,0.6630952,0.009994897,0.00001459229,0.0003759755,0.0000927138,0.04375675],"genre_scores_gemma":[0.5074564,0.2190071,0.002597607,0.2192211,0.02719404,0.00007934936,0.0002213259,0.0001296608,0.02409338],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.007550052,"threshold_uncertainty_score":0.03613418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00535375967025604,"score_gpt":0.2528541680248772,"score_spread":0.2475004083546212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}