{"id":"W2396377009","doi":"10.3727/000000006783980937","title":"Increased Preclinical Efficacy of Irinotecan and Floxuridine Coencapsulated Inside Liposomes Is Associated With Tumor Delivery of Synergistic Drug Ratios","year":2006,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celator Pharmaceuticals (Canada)","funders":"","keywords":"Floxuridine; Irinotecan; In vivo; Pharmacology; Liposome; Chemistry; Antagonism; Drug; In vitro; Drug delivery; Chemotherapy; Medicine; Internal medicine; Cancer; Fluorouracil; Biochemistry; Biology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003767108,0.0007733164,0.0006403368,0.0005131958,0.0001524371,0.0003808171,0.0002629045,0.0003966746,0.0009886944],"category_scores_gemma":[0.0001747995,0.0002626281,0.0003354968,0.0002495176,0.0003484071,0.0004136155,0.0002927978,0.0009848253,0.000268023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004784544,"about_ca_system_score_gemma":0.0003646775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004494277,"about_ca_topic_score_gemma":0.000681211,"domain_scores_codex":[0.999694,0.00006415214,0.00002412808,0.00006722337,0.00007837435,0.00007221182],"domain_scores_gemma":[0.9998543,0.00003413157,0.00004225594,0.00001939846,0.00001718954,0.0000326688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002043535,0.0001159626,0.00009061526,0.00002905203,0.00001104319,0.00001632283,0.00001437356,0.0002116656,0.9977943,0.00005130525,0.00002537813,0.001435633],"study_design_scores_gemma":[0.00001614122,0.0011364,0.0004445176,0.000002039668,0.00001667023,0.000041348,0.000004502025,0.0005234216,0.9974812,0.000008863115,0.0003225634,0.000002308235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944841,0.001134916,0.002727863,0.00008061137,0.00002546395,0.00008707494,0.0001367179,0.000104441,0.001218668],"genre_scores_gemma":[0.9957775,0.0006743542,0.002399813,0.00001867687,0.00001062286,0.00006495856,0.0001594483,0.00002193428,0.0008726863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009886944,"threshold_uncertainty_score":0.003471494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08306341216471885,"score_gpt":0.4170311847761984,"score_spread":0.3339677726114795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}