{"id":"W2396416961","doi":"10.1158/2326-6074.cricimteatiaacr15-a137","title":"Abstract A137: Multi-modal treatment with peptide vaccine, metronomic cyclophosphamide and PD-1 blockade provides effective tumor control through a mechanism of epitope spreading","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Immunovaccine (Canada)","funders":"","keywords":"ELISPOT; Medicine; Immune system; Immunogenicity; Tumor microenvironment; Cancer vaccine; Immunotherapy; Cancer research; Immunology; CD8; Cytotoxic T cell; Epitope; Cancer; Peptide vaccine; Cancer immunotherapy; Cyclophosphamide; Antigen; Biology; Chemotherapy; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008562712,0.0004718166,0.0009749091,0.0003726731,0.0004696446,0.00002764556,0.0004632669,0.0003507507,0.0004884009],"category_scores_gemma":[0.0002215362,0.000291022,0.0001557584,0.000265491,0.001285259,0.0003302845,0.0001453868,0.0006266039,0.0001168953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005859671,"about_ca_system_score_gemma":0.0005739884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004114149,"about_ca_topic_score_gemma":0.0002687592,"domain_scores_codex":[0.9963912,0.001024516,0.0005637584,0.0007651588,0.00009781228,0.001157547],"domain_scores_gemma":[0.9962614,0.002427665,0.0002926629,0.0006635265,0.0003157507,0.00003903377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01487206,0.0003542133,0.007124796,0.00004432906,0.002708493,0.00002642768,0.0009547985,0.000002646095,0.9346436,0.0006100179,0.0000519613,0.03860663],"study_design_scores_gemma":[0.01868648,0.004200176,0.07563047,0.0003908565,0.0001126006,0.000146848,0.0007010914,0.000003607221,0.8932596,0.0002823545,0.006206294,0.0003795559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9275301,0.06876927,0.0005058705,0.0007475699,0.0003304902,0.001807189,0.0001269233,0.00006823975,0.0001144029],"genre_scores_gemma":[0.9884141,0.007878915,0.0001707683,0.00004558675,0.00003909719,0.001288036,0.000008787318,0.00006873684,0.002085936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06850567,"threshold_uncertainty_score":0.9999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236350580915843,"score_gpt":0.3161261455084398,"score_spread":0.2924910874168555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}