{"id":"W2396416961","doi":"10.1158/2326-6074.cricimteatiaacr15-a137","title":"Abstract A137: Multi-modal treatment with peptide vaccine, metronomic cyclophosphamide and PD-1 blockade provides effective tumor control through a mechanism of epitope spreading","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Immunovaccine (Canada)","funders":"","keywords":"ELISPOT; Medicine; Immune system; Immunogenicity; Tumor microenvironment; Cancer vaccine; Immunotherapy; Cancer research; Immunology; CD8; Cytotoxic T cell; Epitope; Cancer; Peptide vaccine; Cancer immunotherapy; Cyclophosphamide; Antigen; Biology; Chemotherapy; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008315658,0.0003434574,0.0002755165,0.0001589137,0.00008560187,0.0002504175,0.0002240529,0.0002989447,0.002661887],"category_scores_gemma":[0.0000713653,0.00008903456,0.000196679,0.00009864762,0.0001288843,0.0001985759,0.0001587518,0.0006157441,0.0003683058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634,"about_ca_system_score_gemma":0.0003356953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004469272,"about_ca_topic_score_gemma":0.0004685442,"domain_scores_codex":[0.999925,0.000007624622,0.00000636555,0.00001940662,0.00001894921,0.00002270483],"domain_scores_gemma":[0.9999577,0.000004758439,0.00001098041,0.0000037344,0.000004220538,0.00001870831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007577929,0.0002891362,0.0001723428,0.00008313006,0.00001438585,0.00003432711,0.0000083835,0.0002808862,0.9908433,0.0001863045,0.0002719119,0.007058016],"study_design_scores_gemma":[0.0003356017,0.006579284,0.002029386,0.0000140608,0.00004793567,0.0004632017,0.000009980859,0.00247437,0.9823653,0.00009939847,0.005574125,0.000007403279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915323,0.001961692,0.003570421,0.0001713024,0.0001274059,0.0001132622,0.0004631036,0.0001496702,0.001910865],"genre_scores_gemma":[0.9945288,0.0004168356,0.002479941,0.00004969516,0.00002596997,0.00005763696,0.0003546617,0.00001558503,0.002070791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002661887,"threshold_uncertainty_score":0.008904874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236350580915843,"score_gpt":0.3161261455084398,"score_spread":0.2924910874168555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}