{"id":"W2396433906","doi":"10.1021/acs.molpharmaceut.5b00073","title":"Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Manitoba Health Research Council","keywords":"Small interfering RNA; Zeta potential; PLGA; Gene knockdown; Chemistry; Transfection; Polyethylenimine; Biophysics; Molecular biology; Nanoparticle; Materials science; Nanotechnology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859207,0.0001873992,0.0001765226,0.00004662656,0.00006863828,0.00002791157,0.0004241058,0.00009185547,0.00001293347],"category_scores_gemma":[0.00005849266,0.0001509105,0.0001510983,0.000152956,0.00008362729,0.000005553101,0.0001651412,0.00008312065,0.00002358386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001626442,"about_ca_system_score_gemma":0.0001310872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003820768,"about_ca_topic_score_gemma":0.000004811348,"domain_scores_codex":[0.9988316,0.00006249048,0.0002885243,0.0002794647,0.0001965946,0.0003413523],"domain_scores_gemma":[0.9989738,0.00002434337,0.00009206409,0.0004156592,0.0003273991,0.0001667601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003352454,0.00007773058,0.00004317689,0.0000176404,0.0001480956,0.000004918863,0.00009972654,0.003408381,0.9872054,0.0000209786,0.006886784,0.001751887],"study_design_scores_gemma":[0.0008300411,0.0004261772,0.00002111896,0.00001027991,0.0001004324,0.000005798416,0.0001767775,0.001698251,0.9374548,0.00003721429,0.05905057,0.0001885954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821343,0.006545048,0.009802977,0.0004606326,0.0003721791,0.0004707977,0.00008224624,0.00001308727,0.0001186923],"genre_scores_gemma":[0.9962271,0.0001574805,0.001808164,0.001171088,0.00008135501,0.00005512955,0.00005120114,0.00002913515,0.0004193696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05216379,"threshold_uncertainty_score":0.6153952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03859021095591168,"score_gpt":0.3006669088402538,"score_spread":0.2620766978843421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}