{"id":"W2396433906","doi":"10.1021/acs.molpharmaceut.5b00073","title":"Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Manitoba Health Research Council","keywords":"Small interfering RNA; Zeta potential; PLGA; Gene knockdown; Chemistry; Transfection; Polyethylenimine; Biophysics; Molecular biology; Nanoparticle; Materials science; Nanotechnology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190448,0.0003092908,0.0001403085,0.0001403045,0.00009414922,0.0002126591,0.000172329,0.0003745259,0.0008057549],"category_scores_gemma":[0.0001396588,0.0001316066,0.0001919848,0.0000883207,0.00007993175,0.0002126216,0.0001098663,0.0002395875,0.0002860697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475615,"about_ca_system_score_gemma":0.0001435822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477097,"about_ca_topic_score_gemma":0.0006765636,"domain_scores_codex":[0.9999182,0.00000781402,0.000005959471,0.00002641093,0.00002832863,0.00001322938],"domain_scores_gemma":[0.9999398,0.000013418,0.00002185105,0.000003947388,0.00001260586,0.000008409176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009840921,0.000007545216,0.00003081504,0.00003392624,0.000001801418,0.0000413239,0.000006276531,0.00004086697,0.9982696,0.00002729757,0.00001194393,0.001518723],"study_design_scores_gemma":[0.000007442594,0.0001807083,0.0006068415,0.000005886965,0.00001273646,0.0001965863,0.00001062467,0.0008099102,0.9954342,0.00001209251,0.002719325,0.000003676146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442215,0.01131058,0.03936401,0.0002729369,0.0001589369,0.0001869171,0.0002903991,0.0002360786,0.003958597],"genre_scores_gemma":[0.96478,0.003968314,0.02563764,0.0001001303,0.00002223012,0.0001033154,0.000217351,0.00003480598,0.005136285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008057549,"threshold_uncertainty_score":0.00269556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03859021095591168,"score_gpt":0.3006669088402538,"score_spread":0.2620766978843421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}