{"id":"W2396492514","doi":"10.1097/01.ta.0000064512.62949.92","title":"Modeling the Two-Hit Hypothesis for Evaluating Strategies to Prevent Organ Injury after Shock/Resuscitation","year":2003,"lang":"en","type":"review","venue":"The Journal of Trauma: Injury, Infection, and Critical Care","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"","keywords":"Resuscitation; Hypertonic saline; Medicine; Intensive care medicine; Shock (circulatory); Population; Organ dysfunction; Sepsis; Anesthesia; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001342068,0.001723305,0.002255898,0.002654253,0.000391942,0.001359517,0.002122535,0.002551491,0.004774234],"category_scores_gemma":[0.001615221,0.0003210525,0.0009382121,0.002049049,0.001047298,0.00250969,0.0008048306,0.002238728,0.003143819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126242,"about_ca_system_score_gemma":0.001574704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001673406,"about_ca_topic_score_gemma":0.002087802,"domain_scores_codex":[0.9996566,0.000132025,0.00003906938,0.00003815601,0.0001159341,0.00001822611],"domain_scores_gemma":[0.9993148,0.0004279273,0.00008438442,0.00002790649,0.0001127574,0.00003227253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001015885,0.0002888929,0.0005155695,0.02927019,0.0002378357,0.0006527392,0.000184158,0.00487611,0.003355017,0.03598229,0.02234933,0.9021863],"study_design_scores_gemma":[0.00005610521,0.0005771649,0.001187845,0.01496619,0.000364271,0.003394249,0.0003526411,0.001885953,0.001832071,0.03356696,0.9417297,0.00008683748],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002189001,0.9934128,0.00306325,0.0006046607,0.0003263188,0.00003638678,0.00002268575,0.00002545573,0.002289549],"genre_scores_gemma":[0.001889296,0.9935109,0.003551834,0.0002517885,0.0001602799,0.00004886946,0.00003016555,0.00000359547,0.0005532898],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004774234,"threshold_uncertainty_score":0.01597142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08423012034572883,"score_gpt":0.4196185235233858,"score_spread":0.3353884031776569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}