{"id":"W2396647400","doi":"10.1021/acs.bioconjchem.5b00619","title":"Synthesis of a Gemcitabine Prodrug for Remote Loading into Liposomes and Improved Therapeutic Effect","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Prostate Cancer Foundation","keywords":"Chemistry; Prodrug; Gemcitabine; Liposome; Pharmacology; Combinatorial chemistry; Chemotherapy; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715804,0.0003005312,0.0002812816,0.0001834164,0.0001295809,0.0001969787,0.0001677866,0.0003273133,0.0006631637],"category_scores_gemma":[0.000136446,0.0001625778,0.0001886414,0.0001347196,0.000137833,0.0002283751,0.0002159914,0.0003637206,0.0003496169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003497161,"about_ca_system_score_gemma":0.0002083399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003453001,"about_ca_topic_score_gemma":0.0005023503,"domain_scores_codex":[0.9999236,0.00001265678,0.00001359818,0.00001984174,0.00001807312,0.00001220453],"domain_scores_gemma":[0.9999553,0.000006665658,0.000012217,0.000007833105,0.000008845262,0.000009183908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003100129,0.00001150395,0.00003388054,0.00003054402,0.00000190311,0.00004261362,0.00001162054,0.0001186163,0.9975194,0.0001591094,0.00001878732,0.002020917],"study_design_scores_gemma":[0.00001738553,0.0001357678,0.0003050782,0.000002789534,0.000006669497,0.00009361197,0.000002632766,0.0003903688,0.9972579,0.00002224052,0.001761733,0.000003914358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649444,0.003147575,0.02763269,0.0002310236,0.00004897772,0.0003616319,0.0003682651,0.0002467973,0.00301857],"genre_scores_gemma":[0.9711964,0.00125572,0.02418814,0.00007015727,0.000008104142,0.000116046,0.0002683288,0.00004374119,0.002853446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006631637,"threshold_uncertainty_score":0.00253737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354415561083223,"score_gpt":0.245871348990554,"score_spread":0.2323271933797218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}