{"id":"W2396715364","doi":"10.3324/haematol.2016.146126","title":"Immunoglobulin heavy and light chain gene features are correlated with primary cold agglutinin disease onset and activity","year":2016,"lang":"en","type":"letter","venue":"Haematologica","topic":"Blood groups and transfusion","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Helse Sør-Øst RHF; Kreftforeningen","keywords":"Cold agglutinin disease; Antibody; Immunoglobulin light chain; Cold Agglutinin; Immunoglobulin heavy chain; Gene; Disease; Immunology; Medicine; Biology; Genetics; Pathology; Autoantibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547734,0.0003963082,0.0003602547,0.000738144,0.0006002691,0.0004999118,0.0002657026,0.0009833768,0.002157948],"category_scores_gemma":[0.001860366,0.0002822899,0.0002187688,0.0007437632,0.0006381043,0.0003830721,0.0002534341,0.0006160552,0.0004011027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311347,"about_ca_system_score_gemma":0.0001607327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121818,"about_ca_topic_score_gemma":0.001179409,"domain_scores_codex":[0.9995833,0.00009371177,0.00005615833,0.00009006983,0.00006622112,0.0001105663],"domain_scores_gemma":[0.9985887,0.0006854639,0.000218701,0.00009772924,0.0001318402,0.0002775167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002951576,0.00006767248,0.9607273,0.00001447201,0.00002285163,0.03044134,0.0002107731,0.00004908468,0.004826509,0.00006087222,0.0002937244,0.00299023],"study_design_scores_gemma":[0.00003910816,0.0003522779,0.8337246,0.00001225641,0.00003598541,0.1627976,0.0004695816,0.0004729241,0.001060613,0.000170031,0.0008544041,0.00001057381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981248,0.0001939419,0.00007844253,0.0002500153,0.00001490114,0.000004453987,0.00004373164,0.000003607393,0.001286142],"genre_scores_gemma":[0.9994631,0.00008597835,0.00006314857,0.0001067193,0.00005541785,0.000003905323,0.00004311142,0.000001633745,0.0001769749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002157948,"threshold_uncertainty_score":0.007219076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008607088845290645,"score_gpt":0.2057563355038635,"score_spread":0.1971492466585729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}