{"id":"W2396772514","doi":"10.1016/j.ahj.2004.03.020","title":"Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials","year":2004,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Ramipril; Telmisartan; Medicine; Tolerability; Clinical endpoint; Internal medicine; ACE inhibitor; Myocardial infarction; Cardiology; Stroke (engine); Heart failure; Diabetes mellitus; Valsartan; Placebo; Randomized controlled trial; Clinical trial; Angiotensin-converting enzyme; Adverse effect; Blood pressure; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1502099,0.007016442,0.006446694,0.003768336,0.003440117,0.004508998,0.004379359,0.00683278,0.01879753],"category_scores_gemma":[0.1305571,0.005087256,0.005823779,0.002719776,0.008374548,0.002965199,0.002211935,0.009119181,0.006432865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003342345,"about_ca_system_score_gemma":0.01156962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220988,"about_ca_topic_score_gemma":0.002440584,"domain_scores_codex":[0.8953755,0.07863307,0.008790057,0.007178588,0.007342805,0.002680159],"domain_scores_gemma":[0.9518014,0.02444666,0.00742586,0.00580155,0.005946761,0.004577903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5076033,0.01989601,0.04147676,0.04023492,0.01575316,0.002119039,0.004524097,0.007963934,0.007407726,0.1161161,0.08193127,0.1549738],"study_design_scores_gemma":[0.644821,0.04477398,0.03204962,0.008839912,0.01559167,0.001719813,0.0009894931,0.01305237,0.004462431,0.06283887,0.1700189,0.0008419073],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02634454,0.008667662,0.04364005,0.009987051,0.004912239,0.8927858,0.007611934,0.0003518514,0.005698984],"genre_scores_gemma":[0.05218239,0.001057233,0.04351472,0.008361544,0.0009389982,0.8907209,0.00167682,0.00004716095,0.001500274],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1502099,"threshold_uncertainty_score":0.7943951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04296914592023787,"score_gpt":0.3341866610844291,"score_spread":0.2912175151641912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}