{"id":"W2396772514","doi":"10.1016/j.ahj.2004.03.020","title":"Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials","year":2004,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":382,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre","funders":"","keywords":"Ramipril; Telmisartan; Medicine; Tolerability; Clinical endpoint; Internal medicine; ACE inhibitor; Myocardial infarction; Cardiology; Stroke (engine); Heart failure; Diabetes mellitus; Valsartan; Placebo; Randomized controlled trial; Clinical trial; Angiotensin-converting enzyme; Adverse effect; Blood pressure; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.04481557,0.0004771704,0.006460228,0.0003598748,0.0002429265,0.0001235175,0.00008216661,0.0000695861,0.000007012012],"category_scores_gemma":[0.009882089,0.0002627034,0.0003337229,0.00059298,0.0005448989,0.0002590892,0.00005055851,0.0005858829,1.108087e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162513,"about_ca_system_score_gemma":0.0006011871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380761,"about_ca_topic_score_gemma":0.0006534933,"domain_scores_codex":[0.9806141,0.01467148,0.002696147,0.0005383724,0.001074265,0.0004056487],"domain_scores_gemma":[0.9881116,0.009228929,0.001453454,0.0003237926,0.0006569537,0.0002253057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8452054,0.002768279,0.1381092,0.00007694939,0.002729443,0.00007812663,0.00332658,0.0008855578,0.0001032383,0.00004098224,0.00001247363,0.006663857],"study_design_scores_gemma":[0.7712805,0.002440401,0.2159656,0.0004482943,0.003478696,0.00005051518,0.002399419,0.003203528,0.00004747695,0.0004201057,0.00001923322,0.0002463266],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743358,0.004130042,0.008018799,0.001591392,0.00009186337,0.01176695,0.00004629056,0.00001514789,0.000003721019],"genre_scores_gemma":[0.9933781,0.002314906,0.003388156,0.0003625684,0.0000824538,0.0003916855,0.00004802213,0.00003219462,0.00000191172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0778564,"threshold_uncertainty_score":0.9999825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04296914592023787,"score_gpt":0.3341866610844291,"score_spread":0.2912175151641912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}