{"id":"W2396829420","doi":"10.1158/1557-3125.advbc15-a15","title":"Abstract A15: Using genetic and pharmacological methods to explore role of the methyltransferase Ezh2 in mouse mammary tumorigenesis","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"EZH2; Carcinogenesis; Biology; Cancer research; Epigenetics; Histone H3; PRC2; Histone methyltransferase; Receptor tyrosine kinase; Gene silencing; Genetically modified mouse; Cancer; Malignant transformation; Histone; Transgene; Kinase; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004908728,0.0007869112,0.0004557628,0.001277471,0.0004501147,0.0006062444,0.0007430834,0.001370512,0.006141837],"category_scores_gemma":[0.0002067221,0.0005168358,0.0009564994,0.0004395598,0.0007238855,0.0005982409,0.0005853298,0.002561507,0.002143024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007627172,"about_ca_system_score_gemma":0.0004896865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291875,"about_ca_topic_score_gemma":0.001775519,"domain_scores_codex":[0.9993315,0.00007128452,0.00008134748,0.0002075564,0.0001550818,0.0001532813],"domain_scores_gemma":[0.9995502,0.00006922769,0.0001138548,0.00006020654,0.00003862099,0.0001678647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00018923,0.0001140903,0.000136314,0.0000501911,0.000008720102,0.00008798679,0.00002230292,0.0000578003,0.9973483,0.0004329555,0.0001549243,0.001397204],"study_design_scores_gemma":[0.00007330049,0.0006297366,0.001717488,0.00001601606,0.00002371476,0.0002994771,0.00003342156,0.0007144748,0.9895375,0.0001756058,0.006769574,0.000009678336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9158029,0.005761276,0.04717671,0.002003813,0.0006914974,0.0009482563,0.01071647,0.001823717,0.01507539],"genre_scores_gemma":[0.9013004,0.004100202,0.03694008,0.0007718075,0.0001112897,0.002103415,0.006601374,0.0005856698,0.04748573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006141837,"threshold_uncertainty_score":0.0205465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09918375553515701,"score_gpt":0.4421464817518032,"score_spread":0.3429627262166462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}