{"id":"W2396829420","doi":"10.1158/1557-3125.advbc15-a15","title":"Abstract A15: Using genetic and pharmacological methods to explore role of the methyltransferase Ezh2 in mouse mammary tumorigenesis","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"EZH2; Carcinogenesis; Biology; Cancer research; Epigenetics; Histone H3; PRC2; Histone methyltransferase; Receptor tyrosine kinase; Gene silencing; Genetically modified mouse; Cancer; Malignant transformation; Histone; Transgene; Kinase; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000972798,0.0001376872,0.000165329,0.0001290284,0.00007169562,0.00001960861,0.0003390483,0.000126441,0.00002911337],"category_scores_gemma":[0.0001555677,0.00009106856,0.00007635907,0.0003064758,0.0001360527,0.000005099426,0.0002748379,0.0001358158,8.999141e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005460168,"about_ca_system_score_gemma":0.0001758402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003612654,"about_ca_topic_score_gemma":0.00005228048,"domain_scores_codex":[0.9980035,0.0006076685,0.000259839,0.0004336591,0.0003219149,0.0003733845],"domain_scores_gemma":[0.9992287,0.00006332681,0.00003853072,0.00036755,0.0001651986,0.0001367118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000799996,0.00004127506,0.004903068,0.00001571655,0.00003305154,0.000006937239,0.00008124293,0.000413378,0.9465168,0.00002179992,0.000004592856,0.04788221],"study_design_scores_gemma":[0.0003759083,0.0001022616,0.01969934,0.00002541964,0.00001046605,0.000001163917,0.00003469209,0.00008179774,0.9782969,0.0004074371,0.0008379815,0.0001266717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733629,0.008547461,0.01717332,0.0003670561,0.00004643653,0.000422828,0.00001665482,0.000003735982,0.00005959295],"genre_scores_gemma":[0.9873567,0.002245546,0.01009533,0.00006426767,0.0000499441,0.000115542,0.000001577549,0.00002680532,0.00004430622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04775554,"threshold_uncertainty_score":0.3713668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09918375553515701,"score_gpt":0.4421464817518032,"score_spread":0.3429627262166462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}