{"id":"W2397191612","doi":"10.1097/cmr.0000000000000175","title":"A phase 2 study of tremelimumab in patients with advanced uveal melanoma","year":2015,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Occupational Cancer Research Centre; Royal Victoria Hospital; Princess Margaret Cancer Centre","funders":"Pfizer","keywords":"Tremelimumab; Medicine; Clinical endpoint; Interim analysis; Internal medicine; Confidence interval; Phases of clinical research; Melanoma; Immunotherapy; Oncology; Clinical trial; Ipilimumab; Surgery; Gastroenterology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006616723,0.0001274091,0.000386995,0.0003968135,0.00004921527,0.000005967187,0.0001240271,0.00008513084,0.00005051038],"category_scores_gemma":[0.0001629728,0.00009011557,0.00002732833,0.0005738757,0.0001143182,0.00008027464,0.00007534824,0.0003300762,0.00005899839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390433,"about_ca_system_score_gemma":0.0002904989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002025386,"about_ca_topic_score_gemma":0.0002476434,"domain_scores_codex":[0.9978061,0.0003368787,0.0002591184,0.0003112983,0.0008946912,0.0003919542],"domain_scores_gemma":[0.9987791,0.00009044106,0.00005150885,0.0004161869,0.000445851,0.0002169624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01278197,0.02449581,0.9426127,0.00002120818,0.0001438687,0.0005981865,0.001711633,0.000002662301,0.00003739789,0.00001284085,0.00009949335,0.01748222],"study_design_scores_gemma":[0.1254349,0.08844224,0.7825918,0.0000586333,0.00005069712,0.00000773366,0.002395902,0.0000296376,0.0005103162,0.00003709905,0.0003470785,0.00009397925],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944335,0.0001132959,0.000001408481,0.00009758126,0.00004386848,0.001540936,0.000006692539,0.00001493181,0.00374782],"genre_scores_gemma":[0.9992027,0.000002175158,0.0001962921,0.000009447378,0.00002363941,0.000102596,0.00003705531,0.00002072361,0.0004053293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1600209,"threshold_uncertainty_score":0.3674806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07507798544206976,"score_gpt":0.4111785790232871,"score_spread":0.3361005935812174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}