{"id":"W2397191612","doi":"10.1097/cmr.0000000000000175","title":"A phase 2 study of tremelimumab in patients with advanced uveal melanoma","year":2015,"lang":"en","type":"article","venue":"Melanoma Research","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; Occupational Cancer Research Centre; Royal Victoria Hospital; Princess Margaret Cancer Centre","funders":"Pfizer","keywords":"Tremelimumab; Medicine; Clinical endpoint; Interim analysis; Internal medicine; Confidence interval; Phases of clinical research; Melanoma; Immunotherapy; Oncology; Clinical trial; Ipilimumab; Surgery; Gastroenterology; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002643631,0.001443128,0.002026103,0.0004037118,0.0004953102,0.000681053,0.0004565448,0.0009404728,0.002089085],"category_scores_gemma":[0.001052372,0.0006257989,0.001024974,0.0002854621,0.0006760958,0.0005954927,0.0003194413,0.001994654,0.0005713372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005818786,"about_ca_system_score_gemma":0.001257024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006005323,"about_ca_topic_score_gemma":0.001456773,"domain_scores_codex":[0.9993542,0.0003895395,0.0000243129,0.00007730463,0.00005592038,0.00009881502],"domain_scores_gemma":[0.9994367,0.00009115885,0.00007603087,0.00004638415,0.00003701373,0.0003127473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6314616,0.1189974,0.02698387,0.001177948,0.00131475,0.001693553,0.0007398783,0.002590123,0.0915297,0.0005125745,0.003786996,0.1192116],"study_design_scores_gemma":[0.4920342,0.4749897,0.024708,0.0000296838,0.0002994485,0.0005589913,0.00005791058,0.001227041,0.002818071,0.0001844963,0.003064571,0.00002799328],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935494,0.001204697,0.0005083318,0.0002768746,0.00008691042,0.002704038,0.0003886457,0.00005015246,0.001231008],"genre_scores_gemma":[0.9900268,0.001278201,0.00172912,0.0007716739,0.000218425,0.003230445,0.000867337,0.00001896133,0.001859019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002643631,"threshold_uncertainty_score":0.01398104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07507798544206976,"score_gpt":0.4111785790232871,"score_spread":0.3361005935812174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}