{"id":"W2397309492","doi":"","title":"The hepatitis C virus NS5B RNA-dependent RNA polymerase activity and susceptibility to inhibitors is modulated by metal cations.","year":2001,"lang":"en","type":"article","venue":"PubMed","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"NS5B; RNA polymerase; RNA-dependent RNA polymerase; Chemistry; Cofactor; Enzyme; RNA; Hepatitis C virus; Polymerase; Biochemistry; Molecular biology; Biology; Virology; Virus; Gene; Hepacivirus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159854,0.0003298318,0.0002755866,0.0001042306,0.000127659,0.0003818101,0.0001855034,0.0002988244,0.0007910934],"category_scores_gemma":[0.0002652857,0.0001495087,0.0001942076,0.00009430583,0.0001763005,0.0001776042,0.0001537096,0.0002132006,0.0003616685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977693,"about_ca_system_score_gemma":0.0001430102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009092201,"about_ca_topic_score_gemma":0.001032001,"domain_scores_codex":[0.9998282,0.00003465861,0.00001616205,0.00003820353,0.00004094783,0.00004165384],"domain_scores_gemma":[0.9998583,0.00003624642,0.00004658747,0.00001372154,0.00002971214,0.00001541515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002651411,0.00001328167,0.0008548546,0.00007236765,0.000007653478,0.00002535034,0.00001217771,0.00005583048,0.9966995,0.00001953054,0.00002316351,0.001951146],"study_design_scores_gemma":[0.00001502716,0.0002452224,0.01027388,0.000009071563,0.00002107726,0.0001939219,0.00002369766,0.000586744,0.9863619,0.00002835219,0.002234147,0.000007028235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898997,0.006643163,0.001844184,0.00010048,0.00001991295,0.00002293573,0.0002611899,0.00005417781,0.00115433],"genre_scores_gemma":[0.9959033,0.001628826,0.001163684,0.00002822993,0.000008170661,0.00001595896,0.000258645,0.00001021707,0.0009829953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009092201,"threshold_uncertainty_score":0.002646506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436032910303051,"score_gpt":0.2827288012355965,"score_spread":0.258368472132566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}