{"id":"W2397516852","doi":"10.5966/sctm.2015-0245","title":"Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial","year":2016,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":495,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Montpellier; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; European Commission","keywords":"Medicine; Osteoarthritis; Adverse effect; Clinical endpoint; Stromal vascular fraction; Mesenchymal stem cell; Clinical trial; Placebo; Knee pain; Internal medicine; Surgery; Adipose tissue; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878738,0.001191322,0.00175161,0.0004192411,0.0002484399,0.0008966253,0.0006864956,0.00091017,0.002527413],"category_scores_gemma":[0.0007900858,0.0003013705,0.00107786,0.0004798563,0.0008259038,0.0005670792,0.0003450742,0.001967614,0.0004606928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000381788,"about_ca_system_score_gemma":0.000705985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001841823,"about_ca_topic_score_gemma":0.0005356725,"domain_scores_codex":[0.9994853,0.0002750282,0.00003886978,0.00007167809,0.00005708433,0.00007209979],"domain_scores_gemma":[0.9994081,0.0001333239,0.0001762591,0.0000631044,0.00004453715,0.0001746319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8003361,0.07153144,0.002909482,0.00170383,0.001364687,0.0001047733,0.0001927538,0.002314761,0.0350812,0.0002360041,0.001201571,0.08302338],"study_design_scores_gemma":[0.5188432,0.4715939,0.004015077,0.00004670498,0.0003990187,0.00009933559,0.00003067121,0.0007528675,0.00297718,0.0001229687,0.001099486,0.0000195971],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912893,0.004208696,0.0006271201,0.0002350687,0.0001221024,0.002146864,0.0003745359,0.00004983298,0.000946538],"genre_scores_gemma":[0.9901409,0.002492778,0.001999827,0.0006985387,0.0002233533,0.002669931,0.0005693673,0.00001273719,0.001192639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527413,"threshold_uncertainty_score":0.009935856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04255619192397645,"score_gpt":0.3217973048278259,"score_spread":0.2792411129038495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}