{"id":"W2397731054","doi":"10.1158/1538-7445.sabcs15-p5-12-02","title":"Abstract P5-12-02: Effect of 5 vs 2.5 mg/day letrozole on residual estrogen levels in post-menopausal women with high BMI - A prospective crossover study","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Women's College Hospital; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Statistics Canada; Sunnybrook Health Science Centre","funders":"","keywords":"Letrozole; Medicine; Breast cancer; Aromatase inhibitor; Tamoxifen; Internal medicine; Estrone; Gynecology; Population; Adverse effect; Estrogen; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003485337,0.001426879,0.002598025,0.0005645824,0.0007374219,0.001126643,0.001260946,0.00207054,0.005148147],"category_scores_gemma":[0.002398644,0.0007143023,0.002220338,0.0005719659,0.001499709,0.001134558,0.0005127677,0.003682424,0.001201943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006421568,"about_ca_system_score_gemma":0.001408688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001399572,"about_ca_topic_score_gemma":0.001403673,"domain_scores_codex":[0.9983287,0.0009050078,0.0001475803,0.0002554612,0.0001248505,0.0002383569],"domain_scores_gemma":[0.9973745,0.0006260384,0.0004217782,0.0003727913,0.0001722249,0.001032684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9539391,0.03584769,0.001499508,0.0001137041,0.0004301823,0.00004567099,0.00005522908,0.00008277886,0.003594311,0.00002272198,0.0001937266,0.004175305],"study_design_scores_gemma":[0.3374398,0.6510195,0.009340432,0.00001429868,0.0004141475,0.00003802548,0.00003891865,0.0002028218,0.001066268,0.00005594305,0.0003516222,0.00001815499],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965116,0.0004858728,0.0002568198,0.0001188475,0.0001525152,0.001532448,0.0004512807,0.00003261195,0.0004579094],"genre_scores_gemma":[0.9939556,0.0003658164,0.0007577607,0.000350148,0.0002893321,0.00182206,0.000764054,0.00001695025,0.001678299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005148147,"threshold_uncertainty_score":0.01843244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473400600317095,"score_gpt":0.336561030988046,"score_spread":0.321827024984875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}