{"id":"W2397865238","doi":"10.1055/s-2004-825633","title":"Nonviral Gene Therapy Approaches to Hemophilia","year":2004,"lang":"en","type":"review","venue":"Seminars in Thrombosis and Hemostasis","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Genetic enhancement; Vector (molecular biology); Transgene; Vectors in gene therapy; Viral vector; Gene delivery; Factor IX; Biology; Gene; Medicine; Virology; Immunology; Computational biology; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000582204,0.001149765,0.001191841,0.002539217,0.0004345895,0.0008056007,0.001231733,0.001385258,0.004723966],"category_scores_gemma":[0.0004591441,0.0003414552,0.000488287,0.001766989,0.001062127,0.001221292,0.0006508057,0.002145357,0.004048856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007660256,"about_ca_system_score_gemma":0.0005750396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006666842,"about_ca_topic_score_gemma":0.001106052,"domain_scores_codex":[0.9997612,0.00004064234,0.00001789678,0.00004725298,0.0001124821,0.00002058338],"domain_scores_gemma":[0.9998258,0.00008459957,0.00002088649,0.00001327,0.0000370628,0.00001846386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007584619,0.0002005484,0.0001255127,0.008365139,0.00005943643,0.0007187575,0.0001353391,0.000464761,0.01377556,0.009096632,0.02545166,0.9415308],"study_design_scores_gemma":[0.0000352194,0.0001556327,0.00062766,0.0009826829,0.0000509086,0.003527942,0.00004451741,0.000113063,0.004297868,0.004037015,0.9861055,0.00002203761],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003096124,0.9951417,0.001009069,0.0001701476,0.0003699244,0.00001585709,0.0000102087,0.00002050369,0.002952958],"genre_scores_gemma":[0.00166021,0.9937119,0.0007270667,0.0002763629,0.000212998,0.00002414452,0.00003857254,0.000006114691,0.00334252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004723966,"threshold_uncertainty_score":0.01580322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1811872873258302,"score_gpt":0.3742755847050259,"score_spread":0.1930882973791958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}