{"id":"W2398056138","doi":"10.1007/s00018-016-2272-4","title":"Stress transgenerationally programs metabolic pathways linked to altered mental health","year":2016,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Alberta Centre for Child, Family and Community Research; University of Lethbridge","keywords":"Biology; Mental health; Metabolomics; Psychology; Identification (biology); Downregulation and upregulation; Metabolic pathway; Bioinformatics; Genetics; Computational biology; Gene; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243621,0.0007529735,0.0004516463,0.0005324236,0.0002853367,0.0006758329,0.0004406319,0.0005127862,0.003942485],"category_scores_gemma":[0.0002115283,0.000274242,0.0005699633,0.0002333367,0.00076518,0.0004811252,0.0004364792,0.001517639,0.0004195317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005536922,"about_ca_system_score_gemma":0.0005178326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001335793,"about_ca_topic_score_gemma":0.003386639,"domain_scores_codex":[0.9997206,0.0000152776,0.00001687813,0.0001345434,0.00003680159,0.0000757247],"domain_scores_gemma":[0.9996983,0.00003742491,0.00008671854,0.00004497732,0.00002475011,0.0001078129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004869917,0.0001120247,0.0002364471,0.0000215646,0.00001310787,0.0000662695,0.0000340521,0.00006433844,0.9964593,0.0002925602,0.0001114367,0.0021019],"study_design_scores_gemma":[0.00008026074,0.0009313234,0.01176413,0.0000219791,0.0001104438,0.0002290844,0.0003515175,0.00157749,0.9802687,0.000694947,0.003930473,0.00003968749],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885308,0.0008855019,0.006255415,0.0004650825,0.0004421305,0.00004155256,0.001379073,0.0004456947,0.001554739],"genre_scores_gemma":[0.9897106,0.0006200734,0.002081796,0.0001952637,0.00004772245,0.00006284787,0.0006963463,0.000161861,0.006423567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003942485,"threshold_uncertainty_score":0.01318896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03942272488253307,"score_gpt":0.2666403598456982,"score_spread":0.2272176349631652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}