{"id":"W2398072517","doi":"10.1210/en.2016-1106","title":"A Mixture Reflecting Polybrominated Diphenyl Ether (PBDE) Profiles Detected in Human Follicular Fluid Significantly Affects Steroidogenesis and Induces Oxidative Stress in a Female Human Granulosa Cell Line","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Polybrominated diphenyl ethers; Follicular fluid; Oxidative stress; Endocrinology; Internal medicine; Granulosa cell; Reactive oxygen species; Proinflammatory cytokine; Chemistry; Follicular phase; Oxidative phosphorylation; Biology; Cell biology; Biochemistry; Oocyte; Embryo; Inflammation; Medicine; Pollutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001932366,0.0003567336,0.0004265739,0.0002537394,0.0001455717,0.00002412426,0.0003368289,0.0002083523,0.0005277785],"category_scores_gemma":[0.0001450778,0.0002708932,0.00004111878,0.0005243754,0.0003462696,0.0002164766,0.0002924818,0.0003072091,0.00003041417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961276,"about_ca_system_score_gemma":0.00002030576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008206847,"about_ca_topic_score_gemma":0.005220823,"domain_scores_codex":[0.9972278,0.0005310256,0.0003799116,0.000745482,0.0002101285,0.0009056015],"domain_scores_gemma":[0.9991173,0.0001947204,0.0001845826,0.0003664983,0.000003729599,0.0001331895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003947074,0.0001539733,0.06945509,0.00001078265,0.00001675712,0.0002098053,0.001414761,0.000002377837,0.9213532,0.00000797812,0.000006158032,0.007329612],"study_design_scores_gemma":[0.0014299,0.0003295136,0.2857776,0.00006001454,0.00001253838,0.00002570957,0.0003453282,0.000004603504,0.7116451,0.0001083229,0.00001014087,0.0002512714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984715,0.00018948,0.00002926239,0.0001830221,0.00005405718,0.0005880298,0.00007606489,0.00008634797,0.0003222571],"genre_scores_gemma":[0.9992728,0.00002055458,0.0002340037,0.00004328035,0.00003513628,0.00004311525,0.000003192193,0.00004975939,0.0002981272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2163225,"threshold_uncertainty_score":0.9999743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931945892191614,"score_gpt":0.2765695821489841,"score_spread":0.257250123227068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}