{"id":"W2398072517","doi":"10.1210/en.2016-1106","title":"A Mixture Reflecting Polybrominated Diphenyl Ether (PBDE) Profiles Detected in Human Follicular Fluid Significantly Affects Steroidogenesis and Induces Oxidative Stress in a Female Human Granulosa Cell Line","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Polybrominated diphenyl ethers; Follicular fluid; Oxidative stress; Endocrinology; Internal medicine; Granulosa cell; Reactive oxygen species; Proinflammatory cytokine; Chemistry; Follicular phase; Oxidative phosphorylation; Biology; Cell biology; Biochemistry; Oocyte; Embryo; Inflammation; Medicine; Pollutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000975922,0.0002033354,0.0001794754,0.0001773319,0.0001420343,0.0001626688,0.00007366661,0.0002057434,0.0005632878],"category_scores_gemma":[0.0001052792,0.0001078718,0.0001906228,0.0001793319,0.0001373941,0.00008517056,0.000149195,0.0002203837,0.0001527769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118697,"about_ca_system_score_gemma":0.0001613469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011389,"about_ca_topic_score_gemma":0.001547183,"domain_scores_codex":[0.9998677,0.00002154226,0.00001406946,0.00003223636,0.00004356412,0.00002089944],"domain_scores_gemma":[0.9999636,0.000008251241,0.00001012499,0.00000433308,0.000008620762,0.000005116437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391125,0.00001155897,0.0008567233,0.00002849295,0.000006323612,0.00005633729,0.00001843685,0.00002697232,0.9976891,0.000009592078,0.0000237183,0.001133627],"study_design_scores_gemma":[0.00001576946,0.000436673,0.02128241,0.00001051088,0.00004219772,0.000574974,0.0001202312,0.0002776574,0.9743237,0.0000449019,0.002864729,0.000006252293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936557,0.003309807,0.001807585,0.00009979803,0.00002719396,0.00002964803,0.0005507115,0.0000205672,0.0004990678],"genre_scores_gemma":[0.9918646,0.002248346,0.002950675,0.000117353,0.00001097735,0.00004440869,0.001015648,0.000008010174,0.00174003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011389,"threshold_uncertainty_score":0.002010942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931945892191614,"score_gpt":0.2765695821489841,"score_spread":0.257250123227068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}