{"id":"W2398074214","doi":"10.1158/1535-7163.targ-15-a188","title":"Abstract A188: Diazonamide DZ 2384, a potential therapeutic for pancreatic cancer, binds to tubulin with a unique impact on microtubule dynamics and tubulin curvature","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Vinorelbine; Tubulin; Microtubule; Vinca; Mitosis; Cell biology; Biology; Cancer research; Chemistry; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004920421,0.000302468,0.0001643165,0.0001382597,0.0001452414,0.0001585606,0.0002589352,0.0002296713,0.006345028],"category_scores_gemma":[0.00005373024,0.00008924315,0.0001392016,0.0001215684,0.00009912909,0.0001023865,0.0001346226,0.0003827073,0.001452406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641149,"about_ca_system_score_gemma":0.0002347606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008350899,"about_ca_topic_score_gemma":0.0007534569,"domain_scores_codex":[0.9999714,0.00000323037,0.000001769347,0.000006148034,0.00001195537,0.000005559161],"domain_scores_gemma":[0.9999819,0.000001760135,0.000005418924,0.000001059333,0.000003833577,0.000006133375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004253905,0.00009920235,0.0005453632,0.0002401435,0.00001878424,0.0003692415,0.00001451677,0.0003825677,0.9742661,0.0008225933,0.002900258,0.01991582],"study_design_scores_gemma":[0.0002908877,0.001524182,0.005439089,0.00002923794,0.00006835064,0.003107562,0.00003087399,0.00146827,0.8782595,0.0004006776,0.1093675,0.00001378872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9284119,0.01915527,0.008834315,0.00178173,0.0005742434,0.0001925619,0.004574501,0.0004700865,0.0360053],"genre_scores_gemma":[0.9491825,0.00879493,0.005319933,0.0004034126,0.00008423046,0.00008461216,0.003903186,0.0000464677,0.03218076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006345028,"threshold_uncertainty_score":0.02122623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129217169998951,"score_gpt":0.2850875188848919,"score_spread":0.2721658018849968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}