{"id":"W2398538728","doi":"10.18632/aging.100949","title":"Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance","year":2016,"lang":"en","type":"article","venue":"Aging","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Mitosis; Anaphase-promoting complex; Biology; Ubiquitin ligase; Cell division control protein 4; Genome instability; Mitotic exit; Cell biology; Protein degradation; Proteasome; Cell cycle; Saccharomyces cerevisiae; Genetics; F-box protein; Ubiquitin; Yeast; Anaphase; Cell; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002985072,0.0001203021,0.0001273042,0.0000160857,0.0001335925,0.00002409753,0.000171798,0.00005365715,0.00001015208],"category_scores_gemma":[0.00006943772,0.00008716598,0.00004840914,0.00003434257,0.0001662048,0.000008771915,0.00009787037,0.00003324619,5.704631e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001582796,"about_ca_system_score_gemma":0.00002961363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003340403,"about_ca_topic_score_gemma":0.0002410449,"domain_scores_codex":[0.9991035,0.00005967904,0.0002229611,0.000304282,0.0000971757,0.0002123543],"domain_scores_gemma":[0.9993522,0.00003370187,0.000141525,0.0003356823,0.00008901245,0.0000479043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003341746,0.0000354078,0.01563571,0.0001028954,0.00002769944,2.031515e-7,0.0005661858,0.000002099885,0.980278,0.00001558441,0.0004430997,0.002859715],"study_design_scores_gemma":[0.0007541795,0.00009625058,0.01800879,0.00004756179,0.00003929785,0.000003146025,0.000189577,0.00025133,0.9785991,0.000147219,0.001685946,0.0001775493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794735,0.0006868776,0.01836142,0.0007888679,0.00004833849,0.0003025544,0.000287712,0.000007401167,0.00004333415],"genre_scores_gemma":[0.9981311,0.00007217189,0.001276312,0.0001018138,0.00007400238,0.00001212277,0.00006827452,0.00001796162,0.0002462341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01865761,"threshold_uncertainty_score":0.3554525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252431828810258,"score_gpt":0.2495829843081431,"score_spread":0.2270586660200405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}