{"id":"W2398538728","doi":"10.18632/aging.100949","title":"Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance","year":2016,"lang":"en","type":"article","venue":"Aging","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Mitosis; Anaphase-promoting complex; Biology; Ubiquitin ligase; Cell division control protein 4; Genome instability; Mitotic exit; Cell biology; Protein degradation; Proteasome; Cell cycle; Saccharomyces cerevisiae; Genetics; F-box protein; Ubiquitin; Yeast; Anaphase; Cell; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006486176,0.0002114587,0.0001523617,0.0001762082,0.0001656543,0.0002356767,0.0001070628,0.0001515487,0.0006211113],"category_scores_gemma":[0.0001061591,0.00009119844,0.00009280592,0.0001001192,0.0001556064,0.0001214115,0.0001358453,0.0001715221,0.0002438535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347841,"about_ca_system_score_gemma":0.0002423654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187263,"about_ca_topic_score_gemma":0.001835642,"domain_scores_codex":[0.9999567,0.0000044448,0.000005096853,0.00001296347,0.00001146014,0.000009291939],"domain_scores_gemma":[0.9999262,0.000006101595,0.00003359275,0.000008857632,0.000007520215,0.00001766742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008386879,0.000009665098,0.0005267894,0.0000200167,0.000003811309,0.00006642165,0.000006351875,0.00008624273,0.9971833,0.0001454059,0.00004793392,0.001820121],"study_design_scores_gemma":[0.00001253172,0.0001079682,0.02478019,0.000005409826,0.00001367653,0.0006792804,0.00002100903,0.0009744339,0.9700553,0.0001787294,0.003165935,0.000005628387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947045,0.00213429,0.00172915,0.00009102771,0.00002035922,0.000004535994,0.0002673844,0.00009302486,0.0009557598],"genre_scores_gemma":[0.9976448,0.0004380242,0.0005995703,0.00001345688,0.000004504812,0.000002642274,0.0001947005,0.000009663358,0.001092452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187263,"threshold_uncertainty_score":0.002429068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252431828810258,"score_gpt":0.2495829843081431,"score_spread":0.2270586660200405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}