{"id":"W2398722085","doi":"10.1007/978-1-60327-545-3_9","title":"Screening for Chemical Inhibitors of Heterologous Proteins Expressed in Yeast Using a Simple Growth-Restoration Assay","year":2009,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Heterologous; Yeast; Saccharomyces cerevisiae; Heterologous expression; Growth inhibition; Biochemistry; Plasmid; Biology; Gene; Chemistry; Molecular biology; Cell growth; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008720168,0.002399318,0.00220146,0.001485647,0.0004138959,0.0008140393,0.001175897,0.001032757,0.002037241],"category_scores_gemma":[0.0009643821,0.0007650287,0.001042479,0.001563919,0.0004544539,0.0003668122,0.000805149,0.001355937,0.001483135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005952535,"about_ca_system_score_gemma":0.0006751505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288918,"about_ca_topic_score_gemma":0.002645806,"domain_scores_codex":[0.9980887,0.0002795385,0.0002526685,0.0002553845,0.001007673,0.0001159914],"domain_scores_gemma":[0.9986151,0.0003670639,0.0003626617,0.000181801,0.0003008366,0.0001725264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004946954,0.000111505,0.0001998143,0.00009660039,0.00002196012,0.0000416789,0.0000118377,0.0001489586,0.9978619,0.00003070699,0.00008333361,0.001342128],"study_design_scores_gemma":[0.00002428469,0.000486739,0.001685595,0.00000675229,0.00005064107,0.0001840537,0.0000121611,0.0007310635,0.9952415,0.00001671573,0.001546046,0.00001435593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8162602,0.009787558,0.1487428,0.000673728,0.0002754958,0.002869425,0.01042918,0.003634267,0.007327379],"genre_scores_gemma":[0.8132461,0.01267046,0.1436495,0.0004125976,0.00009275637,0.00244276,0.01456744,0.0005911011,0.01232713],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002399318,"threshold_uncertainty_score":0.006815195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04052769120756976,"score_gpt":0.4011519517835917,"score_spread":0.3606242605760219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}