{"id":"W2398854507","doi":"10.1021/acs.biomac.5b00576","title":"Galactose-based Thermosensitive Nanogels for Targeted Drug Delivery of Iodoazomycin Arabinofuranoside (IAZA) for Theranostic Management of Hypoxic Hepatocellular Carcinoma","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions","keywords":"Nanogel; Drug delivery; Cytotoxicity; Hepatocellular carcinoma; Cancer research; Targeted drug delivery; Chemistry; Asialoglycoprotein receptor; Radiation therapy; Hypoxia (environmental); Materials science; Nanotechnology; Medicine; Biochemistry; In vitro; Hepatocyte; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007402914,0.0002432679,0.0001100732,0.0001027646,0.0000472368,0.0001097318,0.00009841562,0.0001543232,0.0003412205],"category_scores_gemma":[0.00007040577,0.00007565603,0.0001401414,0.0000517299,0.000101048,0.0001943289,0.0001438113,0.0002237937,0.00009044273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734613,"about_ca_system_score_gemma":0.0001521756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004139693,"about_ca_topic_score_gemma":0.0005885238,"domain_scores_codex":[0.9999739,0.000004523751,0.000002115705,0.000005460043,0.000007664135,0.000006350072],"domain_scores_gemma":[0.9999751,0.00000356662,0.000009304747,0.000001702931,0.000004848134,0.000005458638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009156373,0.000003027283,0.00002193481,0.00001915449,0.000001246617,0.00000820201,0.000005158144,0.0000853895,0.9992056,0.00003779129,0.000005057214,0.0005982362],"study_design_scores_gemma":[0.000004567181,0.00009668922,0.0003487032,0.000003186309,0.000006900995,0.00006707424,0.000009435907,0.0009477912,0.9974203,0.00002500537,0.001066905,0.00000350592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788266,0.002237197,0.0177318,0.00007856792,0.00002495523,0.00004869938,0.00008303342,0.0000755826,0.0008936147],"genre_scores_gemma":[0.9874636,0.001238567,0.009913714,0.00005996773,0.000006439518,0.00003902029,0.00008418784,0.00001916967,0.001175246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004139693,"threshold_uncertainty_score":0.001258552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982008252677134,"score_gpt":0.2413304713107783,"score_spread":0.221510388784007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}