{"id":"W2398961132","doi":"10.1021/acs.biochem.6b00427","title":"Heme Trafficking and Modifications during System I Cytochrome <i>c</i> Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; CancerCare Manitoba Foundation","keywords":"Heme; Thioether; Redox; Biogenesis; Cytochrome c; Hemeprotein; Cytochrome; Chemistry; Biochemistry; Biophysics; Biology; Mitochondrion; Stereochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007973267,0.0002591569,0.0002739025,0.00004304638,0.0001058149,0.0000226553,0.0002621286,0.0002951323,0.000009844947],"category_scores_gemma":[0.00006043083,0.0002118636,0.0001323385,0.0001001656,0.0001470158,0.000007864332,0.0001390939,0.00005124323,0.000005485645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004061241,"about_ca_system_score_gemma":0.0001022692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004420297,"about_ca_topic_score_gemma":0.000007651425,"domain_scores_codex":[0.9984224,0.00004317542,0.0004410383,0.0006271879,0.0001930656,0.0002730682],"domain_scores_gemma":[0.9987841,0.00001366253,0.0002149851,0.0007074712,0.0001089468,0.0001707832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005463224,0.0000586275,0.0001836768,0.0001789945,0.00009942045,0.000006753316,0.00002782613,0.000002078568,0.9990304,0.0000253982,0.00009038072,0.0002418496],"study_design_scores_gemma":[0.0007745748,0.00003900047,0.00153134,0.0002257658,0.00004321978,0.00002330718,0.0001765985,0.00001370399,0.9965676,0.00001206792,0.0002991302,0.0002936773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995694,0.002750213,0.0005397719,0.00009360585,0.00005113467,0.0002499716,0.0002608091,0.00005116688,0.0003093364],"genre_scores_gemma":[0.9983023,0.0001510906,0.0006306767,0.00002219421,0.0003225431,0.00008666084,0.0001025944,0.00003969596,0.000342226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002608327,"threshold_uncertainty_score":0.8639548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007341724877707644,"score_gpt":0.2034765590376878,"score_spread":0.1961348341599802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}