{"id":"W2399031292","doi":"","title":"Perspectives on protein evolution from simple exact models.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Generality; Computational biology; Neutral network; Robustness (evolution); Computer science; RNA; Simple (philosophy); Biology; Sequence (biology); Theoretical computer science; Genetics; Artificial intelligence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002258898,0.001427806,0.001304233,0.001382094,0.000712222,0.002010342,0.002338388,0.002622657,0.004632004],"category_scores_gemma":[0.003609525,0.0005695701,0.001357502,0.001147914,0.003132265,0.005680475,0.001759259,0.002793617,0.001805684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002071496,"about_ca_system_score_gemma":0.0007257257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002283742,"about_ca_topic_score_gemma":0.001472006,"domain_scores_codex":[0.9994621,0.0002185911,0.00002563044,0.00006348109,0.0001925874,0.00003771816],"domain_scores_gemma":[0.9989845,0.0006568331,0.00007628598,0.0001326832,0.00009098181,0.00005861938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00001629673,0.00001639939,0.000176068,0.000261237,0.00003561169,0.0000864769,0.00006353504,0.03929616,0.0002768039,0.9481848,0.002652162,0.008934442],"study_design_scores_gemma":[0.0000061373,0.00001139723,0.00004714554,0.00003472219,0.000006789609,0.00004676987,0.00001202264,0.03778818,0.00005646066,0.9534397,0.008544393,0.00000642179],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0232948,0.1493996,0.6404244,0.03757466,0.002603181,0.00007885508,0.0009456471,0.0007110982,0.1449677],"genre_scores_gemma":[0.5303013,0.1729049,0.2486055,0.009032772,0.004439745,0.0006729356,0.001582616,0.0005150155,0.03194524],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004632004,"threshold_uncertainty_score":0.0154956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02276787259173058,"score_gpt":0.1936545296081108,"score_spread":0.1708866570163803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}