{"id":"W2399032539","doi":"10.1007/978-1-4939-1755-6_4","title":"Using Caged Ligands to Study Intracrine Endothelin Signaling in Intact Cardiac Myocytes","year":2014,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Molecular Junctions and Nanostructures","field":"Engineering","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Intracrine; Cell biology; Receptor; Intracellular; Ligand (biochemistry); Signal transduction; Extracellular; Cell; Chemistry; Biology; Paracrine signalling; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077537,0.0002073613,0.0002299965,0.00006547825,0.0002075395,0.0003401826,0.0003718625,0.0004610052,0.0008347016],"category_scores_gemma":[0.0001746547,0.0001279589,0.0001406077,0.00008479261,0.0002671635,0.0003359296,0.0002422931,0.0007077148,0.0001928394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003213287,"about_ca_system_score_gemma":0.0001741774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679558,"about_ca_topic_score_gemma":0.0009363462,"domain_scores_codex":[0.9998608,0.00002274852,0.000006719712,0.00004434046,0.00003505465,0.0000304606],"domain_scores_gemma":[0.9998733,0.00006015793,0.00002605831,0.00001502737,0.00001155496,0.00001390767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003873921,0.00001590235,0.00005889558,0.00002360772,0.000002860191,0.00003811269,0.00002509942,0.0001167579,0.9988351,0.0002868179,0.0000238144,0.0005343687],"study_design_scores_gemma":[0.00001703221,0.0001102819,0.0004957931,0.000004888892,0.000006740041,0.00006799142,0.00003416815,0.001726156,0.9962452,0.00007954537,0.001207156,0.00000499867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9845325,0.0009118692,0.0125796,0.0001603712,0.00005903452,0.00002699665,0.00009636555,0.00004226997,0.001591024],"genre_scores_gemma":[0.9837357,0.0009145787,0.0115971,0.0001482009,0.0000180721,0.00008213807,0.0001627029,0.00004363506,0.003297937],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0008347016,"threshold_uncertainty_score":0.002792358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856659964200578,"score_gpt":0.3509298571510309,"score_spread":0.3323632575090251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}