{"id":"W2399161841","doi":"10.1093/neuonc/nov205.12","title":"ATNT-12PHASE I, TWO-STAGE, OPEN-LABEL, DOSE-ESCALATION STUDY OF BUPARLISIB (BKM120) IN COMBINATION WITH ADJUVANT TEMOZOLOMIDE (TMZ) AND WITH CONCOMITANT RADIATION THERAPY (RT) AND TMZ IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM)","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Concomitant; Internal medicine; Adjuvant; Temozolomide; Gastroenterology; Surgery; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002142491,0.003103111,0.0029466,0.0007062178,0.0006945941,0.001399197,0.001604806,0.001887039,0.004854242],"category_scores_gemma":[0.0009648122,0.001322348,0.001702478,0.0007052285,0.001415201,0.001578669,0.0005079604,0.004834794,0.001557444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002044602,"about_ca_system_score_gemma":0.002675688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001547714,"about_ca_topic_score_gemma":0.005145515,"domain_scores_codex":[0.9992239,0.0003701219,0.00003298882,0.0001275737,0.00008997959,0.0001554505],"domain_scores_gemma":[0.9991463,0.00007086628,0.0001995117,0.00008083696,0.00007102366,0.0004314856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.705515,0.160851,0.004517225,0.001075885,0.001139162,0.0001621072,0.0003883693,0.00322189,0.04709199,0.0003431894,0.007222329,0.06847189],"study_design_scores_gemma":[0.5737225,0.4113554,0.00722158,0.00003199132,0.0003212559,0.0002123264,0.00004584219,0.001370039,0.002937483,0.0001826429,0.002556225,0.00004266781],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838668,0.001871901,0.001119071,0.000728467,0.0002215728,0.006753706,0.002578721,0.0003108876,0.002548855],"genre_scores_gemma":[0.9702209,0.002181632,0.004516903,0.001331702,0.000258456,0.01085759,0.004729114,0.0001055058,0.005798289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004854242,"threshold_uncertainty_score":0.01623905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916867244633596,"score_gpt":0.3136758732714193,"score_spread":0.2845072008250833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}