{"id":"W2399342261","doi":"10.1186/s12977-016-0270-0","title":"CRISPR/Cas9: a double-edged sword when used to combat HIV infection","year":2016,"lang":"en","type":"article","venue":"Retrovirology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; SWORD; Human immunodeficiency virus (HIV); Medicine; Virology; Cas9; Computational biology; Biology; Immunology; Bioinformatics; Genetics; Computer science; World Wide Web; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004808861,0.0005052198,0.000665175,0.0008213468,0.0004494227,0.001399767,0.0007886299,0.001314029,0.003675586],"category_scores_gemma":[0.0006687132,0.000234051,0.0003738111,0.0004398083,0.0008687961,0.0006726069,0.0008914299,0.001492109,0.002081359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135554,"about_ca_system_score_gemma":0.0003567521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003666161,"about_ca_topic_score_gemma":0.0004386358,"domain_scores_codex":[0.9993004,0.00008931805,0.00004718469,0.0001413301,0.0003721669,0.00004965385],"domain_scores_gemma":[0.9997532,0.0000559025,0.00006352048,0.00003801466,0.00003230486,0.00005706697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003529994,0.00008395448,0.0006944553,0.0007315126,0.00008994486,0.0005323086,0.00008742365,0.0007556631,0.7600108,0.01050746,0.01260622,0.2135473],"study_design_scores_gemma":[0.00009051451,0.0006846078,0.001656274,0.0002433459,0.0001256383,0.004220818,0.00008493471,0.004378411,0.6508583,0.005694639,0.3318956,0.00006691687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1512576,0.121502,0.5597236,0.01559555,0.008773599,0.001517149,0.003222332,0.01616603,0.1222422],"genre_scores_gemma":[0.561727,0.05816927,0.2750577,0.00814659,0.001350147,0.0005451685,0.00160516,0.0008244573,0.09257446],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003675586,"threshold_uncertainty_score":0.01229602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370862665907602,"score_gpt":0.2996128818741972,"score_spread":0.2859042552151212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}