{"id":"W2399342261","doi":"10.1186/s12977-016-0270-0","title":"CRISPR/Cas9: a double-edged sword when used to combat HIV infection","year":2016,"lang":"en","type":"article","venue":"Retrovirology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; SWORD; Human immunodeficiency virus (HIV); Medicine; Virology; Cas9; Computational biology; Biology; Immunology; Bioinformatics; Genetics; Computer science; World Wide Web; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138548,0.0001764115,0.0001863802,0.00009013958,0.00005259601,0.00001247232,0.0001476776,0.0002398526,0.0001062137],"category_scores_gemma":[0.00007122391,0.0001412887,0.00008838691,0.00007332516,0.00004955675,0.000003495165,0.000131506,0.00008103874,0.0001780282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002611761,"about_ca_system_score_gemma":0.00002776859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003288303,"about_ca_topic_score_gemma":0.00013684,"domain_scores_codex":[0.9989097,0.00004532219,0.0001915785,0.0004012019,0.00008850238,0.000363738],"domain_scores_gemma":[0.9993185,0.00002051725,0.00004022501,0.0004301666,0.00004792013,0.0001427027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00021927,0.00002897824,0.02733324,0.000009086717,0.00004037401,0.000003737595,0.00006217436,0.00009345885,0.9613472,0.0001053195,0.007634869,0.003122346],"study_design_scores_gemma":[0.002738314,0.00101008,0.04284349,0.00001569388,0.00003423084,0.00005248656,0.00001010374,0.00002921327,0.6838244,0.0001187041,0.2689345,0.0003887567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9020609,0.0001615313,0.09521166,0.00136251,0.0003983791,0.0001887977,0.000008937129,0.00004486285,0.0005624159],"genre_scores_gemma":[0.9966049,0.00006292656,0.0005134176,0.0004039653,0.0003675561,0.00004110203,0.00002231817,0.00003286934,0.001950901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2775228,"threshold_uncertainty_score":0.5761586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370862665907602,"score_gpt":0.2996128818741972,"score_spread":0.2859042552151212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}