{"id":"W2399445258","doi":"10.1093/nar/gkw445","title":"Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD–DNA complexes","year":2016,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"RecBCD; Helicase; Nuclease; Biology; Biophysics; DNA; Dynamics (music); Base pair; Nucleotide; ATP hydrolysis; Adenosine triphosphate; Enzyme; Biochemistry; DNA repair; Physics; ATPase; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008397333,0.0001634802,0.000197277,0.0001095629,0.0001444066,0.00003915461,0.0007869496,0.0002521651,0.0005225865],"category_scores_gemma":[0.0001807931,0.0001243723,0.0001018473,0.0001699649,0.0007002321,0.00001778108,0.0005469045,0.0001845356,0.00008364916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008025966,"about_ca_system_score_gemma":0.000188441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001012634,"about_ca_topic_score_gemma":0.0000185918,"domain_scores_codex":[0.9977767,0.0001098333,0.00036444,0.0003680511,0.0008864947,0.0004944675],"domain_scores_gemma":[0.9987525,0.00006785553,0.0001003948,0.0005436128,0.0003713046,0.0001643858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001097776,0.00008177511,0.004909084,0.00004177314,0.00006186764,0.000002612065,0.00008228229,7.966004e-7,0.9757504,0.0004834653,0.00338254,0.01509363],"study_design_scores_gemma":[0.001039479,0.000414857,0.004054396,0.00005978819,0.00001043207,0.00003913659,0.0005108496,0.00005617952,0.9794344,0.0008240775,0.01330206,0.0002543589],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873225,0.00006909569,0.0004173659,0.0005552932,0.00007449065,0.0001565426,0.0005302211,0.00001747632,0.010857],"genre_scores_gemma":[0.9956473,0.0001288625,0.0007050758,0.00005518617,0.0001493186,0.00002162953,0.0002865748,0.00002943247,0.002976662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01483928,"threshold_uncertainty_score":0.5721956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04432050842832457,"score_gpt":0.3243221923655295,"score_spread":0.2800016839372049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}