{"id":"W2399567181","doi":"10.1038/srep21658","title":"Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Alberta Prion Research Institute","keywords":"Cell biology; Degradation (telecommunications); Small interfering RNA; Membrane; Chemistry; Virology; Biology; Transfection; Biochemistry; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002746426,0.0004563899,0.0004707759,0.0003466913,0.0001907046,0.0005095102,0.0004039222,0.0004946829,0.0007706258],"category_scores_gemma":[0.0001939598,0.0002064392,0.0003501209,0.0001941928,0.0002756591,0.0002921311,0.0002569638,0.0005610125,0.000617145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000444457,"about_ca_system_score_gemma":0.0004189055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001459525,"about_ca_topic_score_gemma":0.001051185,"domain_scores_codex":[0.9996784,0.00007721069,0.00004987941,0.00003876382,0.00008342354,0.00007225816],"domain_scores_gemma":[0.9998152,0.00004795517,0.00003342229,0.00003657769,0.00002369683,0.00004318652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001811027,0.000110747,0.0001098388,0.00003584912,0.00001099194,0.0001029837,0.00002581056,0.00007870528,0.9984089,0.0001481072,0.00005740803,0.0007296525],"study_design_scores_gemma":[0.00003417712,0.0008518943,0.003295453,0.00001619094,0.00003147682,0.0003040244,0.00005212352,0.002051614,0.9911441,0.0001130485,0.002095655,0.00001039762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933009,0.00305079,0.001148557,0.0001165491,0.00003849236,0.0000276042,0.0003123648,0.0001201158,0.001884645],"genre_scores_gemma":[0.9938428,0.001935217,0.001238813,0.0000455128,0.000008733625,0.00005394984,0.0005739137,0.00002502692,0.00227604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459525,"threshold_uncertainty_score":0.00322479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008668511596241135,"score_gpt":0.2253401721414954,"score_spread":0.2166716605452543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}