{"id":"W2399571624","doi":"10.1038/srep26027","title":"Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; START Clinic; Jewish General Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Clusterin; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Apolipoprotein E; Hippocampus; Brain size; Genetic association; Atrophy; Brain Structure and Function; Medicine; Genotype; Imaging genetics; Internal medicine; Disease; Oncology; Neuroscience; Biology; Single-nucleotide polymorphism; Genetics; Gene; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214236,0.0001956732,0.000379139,0.0002793124,0.00009921743,0.00003045956,0.00003982411,0.00004286571,0.00006039668],"category_scores_gemma":[0.0004776134,0.0001393308,0.00005703226,0.0001850426,0.0006545579,0.00006545015,0.0001411778,0.00008208959,0.000003970767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004646911,"about_ca_system_score_gemma":0.0001996809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002689868,"about_ca_topic_score_gemma":0.000004904821,"domain_scores_codex":[0.9975794,0.0002231403,0.0005140972,0.000936964,0.0003890827,0.0003573203],"domain_scores_gemma":[0.9985308,0.0002133073,0.0002099412,0.0005072847,0.00008066811,0.0004579997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004556371,0.000204388,0.9693183,0.0003329665,0.00003814349,0.005514999,0.00009308176,0.00000138901,0.005220879,0.000002364536,0.000679915,0.01403716],"study_design_scores_gemma":[0.002230959,0.001411326,0.992433,0.0009096149,0.0002475856,0.0009168281,0.00001626467,0.0001210531,0.001402854,0.0001374578,0.00004150348,0.000131604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954493,0.001185625,0.00001152076,0.0005055472,0.001320357,0.001332269,0.00001930194,0.00002348238,0.0001525797],"genre_scores_gemma":[0.999575,0.00004746316,0.00005048728,0.0001415722,0.00003040038,0.00005855687,0.0000130592,0.00002115902,0.00006228511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0231146,"threshold_uncertainty_score":0.5681745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636093959993556,"score_gpt":0.3064009625494981,"score_spread":0.2900400229495625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}