{"id":"W2399571624","doi":"10.1038/srep26027","title":"Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; START Clinic; Jewish General Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Clusterin; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Apolipoprotein E; Hippocampus; Brain size; Genetic association; Atrophy; Brain Structure and Function; Medicine; Genotype; Imaging genetics; Internal medicine; Disease; Oncology; Neuroscience; Biology; Single-nucleotide polymorphism; Genetics; Gene; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009863864,0.0008806709,0.0007596289,0.0007234167,0.0008469812,0.0009070051,0.0006195097,0.001046982,0.001709386],"category_scores_gemma":[0.002871485,0.0003044072,0.001086107,0.000903461,0.0004437421,0.000365627,0.0007764162,0.000836578,0.0002159513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561412,"about_ca_system_score_gemma":0.0002905872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009353671,"about_ca_topic_score_gemma":0.007368773,"domain_scores_codex":[0.9990816,0.0001967256,0.00008707448,0.0004346062,0.00009094432,0.0001089928],"domain_scores_gemma":[0.9989377,0.0002884094,0.0002918718,0.0001870732,0.0001084369,0.0001864766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007442825,0.0001653356,0.9752097,0.00006502097,0.001931414,0.001422791,0.0004381097,0.0003861942,0.006401493,0.0002479852,0.0007722842,0.005516945],"study_design_scores_gemma":[0.0001060987,0.0002607626,0.9964375,0.0000162223,0.0006711212,0.0006970325,0.0001763402,0.0005985998,0.0003210998,0.0002612211,0.0004375519,0.00001636663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985292,0.0004847284,0.0001717248,0.00005315872,0.00001716912,0.00000715944,0.0004933639,0.000009783359,0.0002337871],"genre_scores_gemma":[0.9988924,0.00009204007,0.0001573923,0.00004226761,0.00001535359,0.00001234793,0.0005193204,0.00001405149,0.0002548227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009353671,"threshold_uncertainty_score":0.01859844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636093959993556,"score_gpt":0.3064009625494981,"score_spread":0.2900400229495625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}