{"id":"W2399613518","doi":"10.1158/1557-3125.metca15-b02","title":"Abstract B02: mTOR/S6K pathway-dependent metabolic reprogramming in cancer cells mediates resistance to glycolytic inhibitors","year":2016,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Glycolysis; Pentose phosphate pathway; Biology; Cancer research; Glutamine; Metabolic pathway; Flux (metallurgy); Biochemistry; Cell biology; Chemistry; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008626266,0.0002710822,0.0002399132,0.0001696921,0.0001423614,0.0002950513,0.0001769929,0.0002546983,0.00303735],"category_scores_gemma":[0.00007819405,0.00009444551,0.0002114515,0.0002123688,0.0001752056,0.0001361366,0.0001656919,0.0005783759,0.0009417075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200804,"about_ca_system_score_gemma":0.0001598839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000535042,"about_ca_topic_score_gemma":0.0005041682,"domain_scores_codex":[0.9999125,0.00001170727,0.00001028944,0.00001981947,0.00002451676,0.00002121791],"domain_scores_gemma":[0.9999505,0.000008153977,0.0000127032,0.000009859795,0.000005731254,0.00001297864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001823638,0.00004270228,0.0002517435,0.00003492825,0.000004310988,0.00005419625,0.00001545362,0.0000961573,0.9975597,0.0002123831,0.0002100663,0.001336033],"study_design_scores_gemma":[0.00002919364,0.0006399988,0.01082298,0.000008580108,0.00001170742,0.0004029689,0.00005983329,0.001553253,0.9804013,0.0001048007,0.005958261,0.000007072459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9896388,0.0009903717,0.002373631,0.0002072694,0.00005098257,0.00005802658,0.002128803,0.0002533798,0.004298796],"genre_scores_gemma":[0.9930155,0.0005055356,0.001266639,0.00008564344,0.000007956971,0.00005927349,0.001849857,0.00002990366,0.003179766],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00303735,"threshold_uncertainty_score":0.01016098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02789430707369686,"score_gpt":0.3374474398819852,"score_spread":0.3095531328082883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}