{"id":"W2399783955","doi":"10.3109/10428194.2016.1171861","title":"Next-generation sequencing identifies a novel<i>ELAVL1–TYK2</i>fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208","year":2016,"lang":"en","type":"letter","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Institute for Health and Care Research","keywords":"Fusion gene; Gene; Biology; Kinase; DNA sequencing; Cancer research; Genetics; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009785887,0.001663361,0.001848509,0.0009789247,0.0006677631,0.0005469505,0.0006207146,0.001987247,0.0000904191],"category_scores_gemma":[0.00009035535,0.001234333,0.0005101087,0.0009378743,0.0002947683,0.0006820596,0.0004203447,0.0008611999,0.0001433876],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02090207,"about_ca_system_score_gemma":0.005865278,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008581576,"about_ca_topic_score_gemma":0.002178451,"domain_scores_codex":[0.9922656,0.0004055123,0.001624372,0.002442745,0.001522656,0.001739159],"domain_scores_gemma":[0.9958614,0.0003065396,0.000732047,0.001949089,0.0005086476,0.0006422469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001216877,0.0001404788,0.00002371233,0.0004409084,0.0001948598,0.003249673,0.0029653,0.0001230065,0.8091316,0.00008838766,0.1167294,0.06569588],"study_design_scores_gemma":[0.02262574,0.001691871,0.0004466034,0.002244761,0.0006068262,0.002114407,0.0008675757,0.00620976,0.5562511,0.0002396584,0.4042183,0.00248338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9322902,0.001653279,0.002054071,0.05647431,0.002960284,0.003149613,0.0005347143,0.0003217832,0.0005617608],"genre_scores_gemma":[0.5634056,0.001877188,0.001343931,0.396176,0.02546938,0.0006868811,0.002116154,0.0005677278,0.008357137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3688846,"threshold_uncertainty_score":0.9997705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02901257512162485,"score_gpt":0.2439034609333595,"score_spread":0.2148908858117347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}