{"id":"W2399947024","doi":"10.1208/s12248-016-9906-1","title":"Di-Peptide-Modified Gemini Surfactants as Gene Delivery Vectors: Exploring the Role of the Alkyl Tail in Their Physicochemical Behavior and Biological Activity","year":2016,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"National Institute of General Medical Sciences","keywords":"Alkyl; Chemistry; Gene delivery; Pulmonary surfactant; Micelle; Dynamic light scattering; Critical micelle concentration; Monolayer; Peptide; Small-angle X-ray scattering; Biophysics; Nanoparticle; Chemical engineering; Organic chemistry; Aqueous solution; Biochemistry; Scattering; Gene; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003582303,0.0001619366,0.0001663418,0.00001881818,0.0001464711,0.00002861861,0.0005163346,0.00009114189,0.00001195591],"category_scores_gemma":[0.00008817857,0.00006083071,0.0001404346,0.00006561607,0.000282579,0.00001660146,0.0003036494,0.0002464511,0.000003327432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001986724,"about_ca_system_score_gemma":0.0000576841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004134001,"about_ca_topic_score_gemma":0.0000176833,"domain_scores_codex":[0.9989844,0.0002114784,0.0002125529,0.0002000832,0.000136788,0.0002546741],"domain_scores_gemma":[0.9992838,0.00008529529,0.0001517886,0.0003588265,0.00006698291,0.00005329781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001938585,0.00006470977,0.02199742,9.539431e-7,0.00003913554,0.0000023033,0.0001741293,0.000004412744,0.9566898,0.000007289257,0.00004079282,0.02078515],"study_design_scores_gemma":[0.0003073036,0.0001476057,0.1518492,0.00003561824,0.00001758035,0.00009622802,0.0002695568,0.000007404298,0.8466594,0.0003054103,0.0002079844,0.00009669508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986512,0.0007074173,0.00001675618,0.0002638678,0.000132145,0.0001200798,0.00001726771,0.000003259146,0.0000880122],"genre_scores_gemma":[0.9979779,0.001636836,0.000006308262,0.00006819393,0.0002359546,0.00001847375,0.000001294456,0.00001108518,0.00004398781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1298518,"threshold_uncertainty_score":0.2480604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03319601291934211,"score_gpt":0.2476732654942031,"score_spread":0.214477252574861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}