{"id":"W2399947024","doi":"10.1208/s12248-016-9906-1","title":"Di-Peptide-Modified Gemini Surfactants as Gene Delivery Vectors: Exploring the Role of the Alkyl Tail in Their Physicochemical Behavior and Biological Activity","year":2016,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Light Source (Canada); University of Saskatchewan","funders":"National Institute of General Medical Sciences","keywords":"Alkyl; Chemistry; Gene delivery; Pulmonary surfactant; Micelle; Dynamic light scattering; Critical micelle concentration; Monolayer; Peptide; Small-angle X-ray scattering; Biophysics; Nanoparticle; Chemical engineering; Organic chemistry; Aqueous solution; Biochemistry; Scattering; Gene; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003598958,0.0002682589,0.0001656675,0.0001522622,0.0001037826,0.0002945297,0.0001643169,0.0002756184,0.0002882237],"category_scores_gemma":[0.0002840133,0.0001191278,0.0001178088,0.0002461225,0.000184252,0.0003820076,0.0001444179,0.0003228995,0.0001457694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157644,"about_ca_system_score_gemma":0.0001924267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003787643,"about_ca_topic_score_gemma":0.0008279762,"domain_scores_codex":[0.999891,0.00002776798,0.0000100303,0.00001942828,0.00003203337,0.00001968838],"domain_scores_gemma":[0.9998519,0.00004187385,0.00004159691,0.000008422081,0.00002505159,0.00003112046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008380396,0.00001009657,0.000119722,0.00002658761,0.000003573067,0.00002150555,0.00001787105,0.00005368822,0.9982854,0.00009481212,0.000007440912,0.001275559],"study_design_scores_gemma":[0.000004922991,0.0001206766,0.000359307,0.000002070861,0.000009792535,0.00004953194,0.00000760231,0.0005811551,0.9981931,0.00002896094,0.0006404414,0.000002540188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913263,0.00252648,0.005359891,0.00004840801,0.00001082936,0.00002875406,0.00004809593,0.0000312489,0.0006201044],"genre_scores_gemma":[0.9882715,0.002148933,0.00785799,0.00003994996,0.000004475819,0.00002285529,0.000129882,0.00002338944,0.001501008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003787643,"threshold_uncertainty_score":0.001903296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03319601291934211,"score_gpt":0.2476732654942031,"score_spread":0.214477252574861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}