{"id":"W2400101856","doi":"10.1038/leu.2016.145","title":"KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells","year":2016,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"William Lawrence and Blanche Hughes Foundation; Fondation Tuck; Leukemia and Lymphoma Society","keywords":"Tolerability; Myeloid leukemia; Medicine; Haematopoiesis; Leukemia; Progenitor cell; Cancer research; Internal medicine; Pharmacology; Oncology; Immunology; Stem cell; Biology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009300029,0.0004189023,0.0004367651,0.000214941,0.0001355752,0.0002480992,0.0002359479,0.0002393929,0.001299611],"category_scores_gemma":[0.00007280905,0.0001265885,0.0001854067,0.0001845637,0.000146215,0.0002380823,0.0001848149,0.0007445922,0.0006146869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739087,"about_ca_system_score_gemma":0.0001445698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852151,"about_ca_topic_score_gemma":0.0003722024,"domain_scores_codex":[0.9998933,0.00001425853,0.0000108783,0.00002361448,0.00003872352,0.00001921582],"domain_scores_gemma":[0.9999441,0.000005420518,0.00002107606,0.00000646715,0.000006248779,0.00001670288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006099604,0.0003529549,0.000521942,0.0001969014,0.00002812171,0.0002033804,0.00002370713,0.000432933,0.9584337,0.000165881,0.0006439819,0.03838645],"study_design_scores_gemma":[0.0002981693,0.00530958,0.007283348,0.000009804016,0.00004209007,0.003981961,0.00002077649,0.00102054,0.9626525,0.00005486634,0.01930882,0.00001750656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645962,0.01879147,0.008116588,0.0003116951,0.0000812568,0.0001662307,0.0007978561,0.0006525902,0.006486128],"genre_scores_gemma":[0.9805895,0.008501952,0.002606369,0.0001015494,0.00004481632,0.00008087505,0.002288699,0.00003763838,0.005748546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299611,"threshold_uncertainty_score":0.004347682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617706361831362,"score_gpt":0.2453413937067642,"score_spread":0.2291643300884506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}