{"id":"W2400101856","doi":"10.1038/leu.2016.145","title":"KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells","year":2016,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"William Lawrence and Blanche Hughes Foundation; Fondation Tuck; Leukemia and Lymphoma Society","keywords":"Tolerability; Myeloid leukemia; Medicine; Haematopoiesis; Leukemia; Progenitor cell; Cancer research; Internal medicine; Pharmacology; Oncology; Immunology; Stem cell; Biology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003742147,0.0004168375,0.0006939325,0.0002459227,0.0001724481,0.00005911594,0.0001468777,0.0004327021,0.000577414],"category_scores_gemma":[0.0002911846,0.0003223158,0.0000941732,0.000357056,0.00037831,0.0003673539,0.0002189502,0.000532824,0.0001365844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001809983,"about_ca_system_score_gemma":0.00103797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001061612,"about_ca_topic_score_gemma":0.00005804513,"domain_scores_codex":[0.9971064,0.0001462527,0.0007298799,0.0007679472,0.0006225972,0.0006269013],"domain_scores_gemma":[0.9979916,0.0003654845,0.0003579427,0.0004743718,0.0003474636,0.0004631815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000493177,0.00004082786,0.0009177369,0.0001658719,0.0001446593,0.0001268316,0.001540136,0.000002365681,0.9628377,0.00002778519,0.02196895,0.01173398],"study_design_scores_gemma":[0.009500542,0.0007523182,0.008294568,0.0005472623,0.0001042713,0.00008755235,0.0006952386,0.005871175,0.9613146,0.00001979603,0.01229612,0.0005166121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929028,0.0001343971,0.00002543609,0.0006198983,0.0001663999,0.0006925614,0.0001780861,0.0001184994,0.005161881],"genre_scores_gemma":[0.9940821,0.0004473655,0.0007015992,0.001540769,0.0005320039,0.00003018633,0.00008283137,0.0001094973,0.002473646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01121737,"threshold_uncertainty_score":0.9999229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617706361831362,"score_gpt":0.2453413937067642,"score_spread":0.2291643300884506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}