{"id":"W2400307825","doi":"10.1038/srep19360","title":"The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Direction Générale de l’offre de Soins; Université Lille 1 - Sciences et Technologies; Institut National Du Cancer; Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Université de Lille","keywords":"TLR9; Endosome; Cell biology; TLR4; Signalling; Inflammation; Signal transduction; Chemistry; Biology; Immunology; Biochemistry; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009758717,0.0003419824,0.0002001253,0.0003012231,0.0002862473,0.0005662196,0.0001602268,0.0003268331,0.0009907995],"category_scores_gemma":[0.0001090381,0.0001225657,0.0003425225,0.0002162344,0.0002600201,0.0002655572,0.0002311787,0.0007959173,0.0003857536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005538854,"about_ca_system_score_gemma":0.0003381562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001414084,"about_ca_topic_score_gemma":0.0009409363,"domain_scores_codex":[0.9998355,0.00001578931,0.000009419956,0.0000310814,0.00004160503,0.0000666004],"domain_scores_gemma":[0.999892,0.000008009382,0.00003995056,0.000006762416,0.00002320139,0.00003002065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004106852,0.00003226982,0.0007911108,0.00008187489,0.000008125598,0.0001803366,0.00002222238,0.0001207569,0.9943647,0.0002025865,0.0001603947,0.00362477],"study_design_scores_gemma":[0.00003595009,0.000195217,0.03966215,0.00003059348,0.00004847856,0.0009928022,0.00013987,0.002046728,0.9491971,0.0003185194,0.007315593,0.00001699524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841095,0.008171619,0.003602993,0.0003532353,0.00004657798,0.00005029819,0.0009445903,0.0001201337,0.002601098],"genre_scores_gemma":[0.9919406,0.003131132,0.001565057,0.00009808318,0.00001703072,0.00003791471,0.0006566447,0.00001932189,0.002534278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414084,"threshold_uncertainty_score":0.004018784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008628992481445207,"score_gpt":0.1942746603335961,"score_spread":0.1856456678521509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}