{"id":"W2400490882","doi":"","title":"An Orphan Drug Framework (ODF) for Canada.","year":2014,"lang":"en","type":"article","venue":"PubMed","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"","keywords":"Orphan drug; Rare disease; Drug; Medicine; Disease; Pharmacology; Bioinformatics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002597085,0.0006667656,0.0006014125,0.00188047,0.00494566,0.003789239,0.001663643,0.006375262,0.09706319],"category_scores_gemma":[0.01073896,0.0004889943,0.0009812098,0.001808197,0.001555414,0.001452043,0.002104037,0.004470879,0.01722123],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02796282,"about_ca_system_score_gemma":0.213859,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8637244,"about_ca_topic_score_gemma":0.9237419,"domain_scores_codex":[0.9966307,0.0002562701,0.0001040969,0.0002302127,0.002005082,0.0007735426],"domain_scores_gemma":[0.9888301,0.0008555684,0.0003739263,0.0002725367,0.006059254,0.003608533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007286282,0.00004473619,0.0005812952,0.0001874738,0.00001373941,0.0003222568,0.00007147268,0.0001098789,0.0004470525,0.02827897,0.9202219,0.04964834],"study_design_scores_gemma":[0.00003819074,0.00002070344,0.001068682,0.0001758388,0.00001454001,0.0001621358,0.00006571813,0.0001068072,0.0001389137,0.001581269,0.9966078,0.00001950536],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.003282968,0.02539709,0.00416811,0.2372192,0.0104653,0.0009346203,0.02942521,0.002593695,0.6865138],"genre_scores_gemma":[0.04244851,0.02422238,0.02183414,0.1404991,0.001318736,0.0005108073,0.01567364,0.0006916333,0.7528011],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9720372,"threshold_uncertainty_score":0.3247087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004890225117473009,"score_gpt":0.1986137535573625,"score_spread":0.1937235284398895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}