{"id":"W2400560249","doi":"10.1021/acs.orglett.6b01324","title":"Total Synthesis of Teixobactin","year":2016,"lang":"ca","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada; University of California, Los Angeles; Simon Fraser University; University of Sydney","keywords":"Chemistry; Depsipeptide; Natural product; Staphylococcus aureus; Mycobacterium tuberculosis; Total synthesis; Antibacterial activity; Bacteria; Virulence; Peptide; Peptide synthesis; Combinatorial chemistry; Stereochemistry; Pathogenic bacteria; Microbiology; Biochemistry; Tuberculosis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003393597,0.0003160813,0.0006098387,0.0001370639,0.00006675911,0.00001654058,0.0002338383,0.0001963164,0.009439533],"category_scores_gemma":[0.001496797,0.0001842813,0.0002227508,0.0003123961,0.0002806109,0.0001281038,0.000107301,0.0001895314,0.0011366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068186,"about_ca_system_score_gemma":0.0001203175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000606254,"about_ca_topic_score_gemma":0.000004270284,"domain_scores_codex":[0.9979992,0.0001116494,0.0005200435,0.0005227018,0.000333979,0.0005124256],"domain_scores_gemma":[0.9983387,0.0004742199,0.0002772637,0.0006528966,0.00009154321,0.0001654024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001614153,0.0001076824,0.0004515863,0.0001900716,0.0002465405,0.00004014246,0.0000837828,1.881453e-8,0.9245852,0.00003007058,0.03500919,0.0390943],"study_design_scores_gemma":[0.0006395261,0.000101616,0.002519171,0.000947017,0.0004353299,0.00008743654,0.00005459739,4.370371e-7,0.9905845,0.000004318027,0.004342897,0.0002831544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8776188,0.0005117034,0.00004029683,0.1201181,0.0009448437,0.0002788301,0.00008300763,0.00004478239,0.0003595781],"genre_scores_gemma":[0.9947631,0.0002946303,0.0002127788,0.001906284,0.001120482,6.267672e-7,0.000001809895,0.00006147135,0.001638853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1182118,"threshold_uncertainty_score":0.9996411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006901889158145301,"score_gpt":0.2028784948182727,"score_spread":0.1959766056601274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}