{"id":"W2400560249","doi":"10.1021/acs.orglett.6b01324","title":"Total Synthesis of Teixobactin","year":2016,"lang":"ca","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada; University of California, Los Angeles; Simon Fraser University; University of Sydney","keywords":"Chemistry; Depsipeptide; Natural product; Staphylococcus aureus; Mycobacterium tuberculosis; Total synthesis; Antibacterial activity; Bacteria; Virulence; Peptide; Peptide synthesis; Combinatorial chemistry; Stereochemistry; Pathogenic bacteria; Microbiology; Biochemistry; Tuberculosis; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323333,0.0006216286,0.0004316908,0.0003432408,0.0003052366,0.0003563443,0.000257362,0.0001919098,0.003346837],"category_scores_gemma":[0.0001383248,0.0001449841,0.0002102685,0.0003969686,0.0001378705,0.0003143762,0.0004010471,0.0006140425,0.001384538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302928,"about_ca_system_score_gemma":0.0005991234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950661,"about_ca_topic_score_gemma":0.0008023428,"domain_scores_codex":[0.9998513,0.0000137652,0.00001125954,0.00002914668,0.00004936395,0.00004516828],"domain_scores_gemma":[0.9999304,0.000005988959,0.000009379076,0.000008320653,0.00002090131,0.00002505805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001335848,0.00003838168,0.0001081386,0.0003037027,0.00002353028,0.0002905517,0.00008856216,0.0008402022,0.9714897,0.001933993,0.0005314411,0.02421831],"study_design_scores_gemma":[0.00004713174,0.0006461916,0.0009043548,0.00004665079,0.00004459515,0.0006466496,0.00004335612,0.0009456269,0.9265648,0.0006323143,0.06945043,0.00002782264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7983201,0.01201545,0.1147847,0.0003382424,0.0004950218,0.0007566455,0.006450646,0.0009888113,0.06585044],"genre_scores_gemma":[0.8988534,0.01138025,0.05705483,0.0001483208,0.00006676997,0.0003623766,0.004571251,0.0002586858,0.02730418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003346837,"threshold_uncertainty_score":0.01119626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006901889158145301,"score_gpt":0.2028784948182727,"score_spread":0.1959766056601274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}