{"id":"W2400568329","doi":"10.3390/metabo6020016","title":"Metabolic Effect of Estrogen Receptor Agonists on Breast Cancer Cells in the Presence or Absence of Carbonic Anhydrase Inhibitors","year":2016,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; National Research Council Canada; Université de Moncton","funders":"Canadian Institutes of Health Research; New Brunswick Innovation Foundation; Université de Moncton","keywords":"Carbonic anhydrase; Estrogen receptor; Acetazolamide; Chemistry; Cancer cell; Biochemistry; Enzyme; Internal medicine; Breast cancer; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371715,0.0002582476,0.0004128414,0.0001614516,0.000141087,0.0002099163,0.0001421311,0.0001903035,0.000939489],"category_scores_gemma":[0.0001412364,0.0001164328,0.0002116122,0.0003388783,0.0001177549,0.0001311399,0.0001147383,0.0002789845,0.0002234871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002387103,"about_ca_system_score_gemma":0.000317101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003375043,"about_ca_topic_score_gemma":0.005674943,"domain_scores_codex":[0.9998065,0.00004948097,0.00001692819,0.00003107836,0.00005438995,0.00004167384],"domain_scores_gemma":[0.9998974,0.00002923426,0.00001626458,0.0000125846,0.0000294592,0.00001512676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000566176,0.00004746654,0.0002892026,0.00004118368,0.00001126023,0.00005119388,0.00002970488,0.0001215769,0.9974341,0.00003140134,0.00007366134,0.001302951],"study_design_scores_gemma":[0.00001742072,0.0006246911,0.006369422,0.000005283683,0.00002717285,0.00006987107,0.00006936589,0.00078349,0.990423,0.0000200486,0.001581408,0.000008786395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928154,0.00276988,0.0006010566,0.0001736354,0.00004927078,0.00002525569,0.00140516,0.00003589931,0.002124565],"genre_scores_gemma":[0.9870721,0.003021749,0.002708209,0.0001177548,0.00002173141,0.00007395577,0.002899048,0.00001874217,0.004066745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003375043,"threshold_uncertainty_score":0.006710827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006667482056377559,"score_gpt":0.2520686648233635,"score_spread":0.2454011827669859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}