{"id":"W2400737480","doi":"10.1021/acs.jnatprod.6b00295","title":"Condensation of Macrocyclic Polyketides Produced by<i>Penicillium</i>sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway","year":2016,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Science Foundation","keywords":"Stereochemistry; Transamination; Cysteine; Penicillium; Chemistry; Residue (chemistry); Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007327956,0.0002891594,0.0006471719,0.0002435805,0.00007001301,0.00002898681,0.0002565294,0.000133929,0.00005806005],"category_scores_gemma":[0.002139018,0.000144904,0.0001436458,0.0005248542,0.0001525943,0.0005357525,0.00004329761,0.0004163867,0.00001328672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394748,"about_ca_system_score_gemma":0.0004194925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003805885,"about_ca_topic_score_gemma":0.000004965434,"domain_scores_codex":[0.9973841,0.000127228,0.0009119262,0.0004960202,0.000742185,0.0003385476],"domain_scores_gemma":[0.996377,0.0001027307,0.00127903,0.0005419389,0.001511837,0.0001874626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002483573,0.0001525668,0.002040985,0.0001090594,0.0001973263,0.00002375902,0.0001082807,4.337187e-7,0.964098,0.00003026037,0.01214297,0.01861276],"study_design_scores_gemma":[0.00204195,0.0006416744,0.009579981,0.0005564622,0.000215102,0.0005706653,0.00002863732,0.000001585051,0.9812674,0.00007730535,0.004805791,0.0002134364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609947,0.00390969,0.00001489893,0.03392346,0.0004835374,0.0005863477,0.00001631879,0.00002573035,0.0000453802],"genre_scores_gemma":[0.9926502,0.0003725617,0.001538402,0.0002090444,0.0009400806,5.886226e-7,0.000008302205,0.0000355447,0.004245256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03371441,"threshold_uncertainty_score":0.5909014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277640585863207,"score_gpt":0.2343708387477165,"score_spread":0.2215944328890844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}