{"id":"W2400737480","doi":"10.1021/acs.jnatprod.6b00295","title":"Condensation of Macrocyclic Polyketides Produced by<i>Penicillium</i>sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway","year":2016,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Science Foundation","keywords":"Stereochemistry; Transamination; Cysteine; Penicillium; Chemistry; Residue (chemistry); Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370431,0.000647273,0.0003818627,0.0001507023,0.0001067385,0.0003405655,0.0001838198,0.0002898603,0.0004280121],"category_scores_gemma":[0.0002850572,0.0001467909,0.0003475888,0.0002383378,0.0001890419,0.0002227489,0.0001606198,0.0004764709,0.0001937556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003404384,"about_ca_system_score_gemma":0.0002426903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007271969,"about_ca_topic_score_gemma":0.001098528,"domain_scores_codex":[0.9997664,0.00003798095,0.00002016795,0.0000895936,0.00005439399,0.00003148774],"domain_scores_gemma":[0.9997715,0.00003952217,0.00008967484,0.00003693179,0.00002546662,0.00003687703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004823164,0.000006565946,0.000180877,0.00001231289,0.000004241626,0.00002344989,0.000004048234,0.0001098259,0.998596,0.00001194892,0.000004003234,0.0009984145],"study_design_scores_gemma":[0.000003828054,0.0001528274,0.001516441,0.00000124568,0.000005324137,0.00009332918,0.000005487997,0.0003374773,0.9975675,0.000008926837,0.0003036537,0.000004050208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872293,0.0003735954,0.01105106,0.00005717771,0.00001079294,0.00005280227,0.0005370807,0.0001239541,0.0005641537],"genre_scores_gemma":[0.9779692,0.0002891631,0.01987655,0.00004040286,0.000005791818,0.00003493813,0.001027989,0.00003878231,0.0007172409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007271969,"threshold_uncertainty_score":0.002470016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277640585863207,"score_gpt":0.2343708387477165,"score_spread":0.2215944328890844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}