{"id":"W2400894217","doi":"10.1182/blood.v126.23.727.727","title":"Ixazomib, an Investigational Oral Proteasome Inhibitor (PI), in Combination with Lenalidomide and Dexamethasone (IRd), Significantly Extends Progression-Free Survival (PFS) for Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM): The Phase 3 Tourmaline-MM1 Study (NCT01564537)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Ixazomib; Lenalidomide; Medicine; Multiple myeloma; Dexamethasone; Progression-free survival; Oncology; Internal medicine; Proteasome inhibitor; Pegfilgrastim; Miltefosine; Pharmacology; Febrile neutropenia; Neutropenia; Overall survival; Carfilzomib; Chemotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009142246,0.0008002468,0.001224076,0.0003952325,0.0003216355,0.0006624287,0.000556733,0.0007276689,0.00362264],"category_scores_gemma":[0.000493878,0.0004941947,0.0008859179,0.0004865475,0.0007613436,0.0003964268,0.0003460281,0.002034178,0.0004654191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007227241,"about_ca_system_score_gemma":0.001065919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009271699,"about_ca_topic_score_gemma":0.004364371,"domain_scores_codex":[0.9997007,0.0001369409,0.00002116272,0.00005685441,0.00002900031,0.00005537396],"domain_scores_gemma":[0.999706,0.00004089027,0.00009269525,0.0000179826,0.00001161297,0.000130888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9094902,0.02175742,0.004355134,0.0006056231,0.0009819617,0.00007835891,0.00008660473,0.0007799214,0.01981762,0.0001428199,0.001308459,0.04059601],"study_design_scores_gemma":[0.6909938,0.2936118,0.009219173,0.00003966314,0.0008011765,0.000104767,0.00003768598,0.0004228151,0.002959841,0.0001729636,0.001618666,0.0000176652],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922284,0.002427899,0.000305843,0.0004592653,0.0001499905,0.002197569,0.0009865223,0.00006327433,0.001181198],"genre_scores_gemma":[0.9929506,0.001848028,0.0008697661,0.0004449034,0.0001345182,0.001515758,0.0006189403,0.000008463186,0.001609134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00362264,"threshold_uncertainty_score":0.012119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05309745008142338,"score_gpt":0.3334005016023233,"score_spread":0.2803030515209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}