{"id":"W2400927555","doi":"10.1200/jco.2016.66.5844","title":"Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for <i>CH</i><i>EK</i><i>2</i>*1100delC Carriers","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; David Geffen School of Medicine, University of California, Los Angeles; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Erasmus Universitair Medisch Centrum Rotterdam; Russian Academy of Sciences; Cancer Council South Australia; National Health and Medical Research Council; Medical Research Council; University of California, Los Angeles; U.S. Army; School of Medicine, Stanford University; National Institutes of Health; Universitätsklinikum Köln; Universität zu Köln; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Technische Universität München; Sundhed og Sygdom, Det Frie Forskningsråd; Universitetet i Oslo; Leids Universitair Medisch Centrum; Karolinska Institutet; University of Oxford; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; University of Toronto; Cancer Council NSW; Susan G. Komen for the Cure; Universität Heidelberg; Universiteit van Amsterdam; Cancer Council Victoria; University of Melbourne; London School of Hygiene and Tropical Medicine; Eberhard Karls Universität Tübingen; Universiteit Leiden; Kuopion Yliopistollinen Sairaala; Robert Bosch Stiftung; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Pomorski Uniwersytet Medyczny W Szczecinie; Vrije Universiteit Amsterdam; Agency for Science, Technology and Research; King's College London; National Institute for Health and Care Research; Itä-Suomen Yliopisto; Lon V. Smith Foundation; Stockholms Läns Landsting; KWF Kankerbestrijding; Herlev Hospital; Cancer Research UK; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; University of California, Irvine; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancerfonden; U.S. Department of Health and Human Services; Mayo Clinic; Breast Cancer Research Foundation; Cancer Council Tasmania; Francis Crick Institute; Helsingin Yliopisto","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00166104,0.0001776968,0.0006742743,0.00005500508,0.00009007545,0.00002098644,0.0002709076,0.0003216635,0.00007110067],"category_scores_gemma":[0.001436622,0.0001168373,0.0003229265,0.00006726866,0.0004924634,0.00001403372,0.00008785914,0.0002650992,0.000004024212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150468,"about_ca_system_score_gemma":0.00136978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001722138,"about_ca_topic_score_gemma":0.00009475123,"domain_scores_codex":[0.9977659,0.0001982665,0.001245927,0.0003374284,0.0001616967,0.0002907828],"domain_scores_gemma":[0.9967718,0.0008316294,0.001336117,0.0002441525,0.0005289984,0.0002872678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006357395,0.0004623391,0.1448833,0.00004450556,0.001281635,0.0001462681,0.0000898631,0.0001492556,0.1071181,0.000194568,0.1451844,0.5940883],"study_design_scores_gemma":[0.007731046,0.003634006,0.1014002,0.00007752998,0.0003835762,0.0005511043,0.00008729729,0.00002696866,0.01164388,0.001869194,0.872248,0.0003472419],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776037,0.005877855,0.005886787,0.006772143,0.00292558,0.0002584217,0.0003068794,0.000008750756,0.000359831],"genre_scores_gemma":[0.9762827,0.007082803,0.01183904,0.001541941,0.002880308,0.0000341088,0.000005218297,0.00004168228,0.0002922353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7270635,"threshold_uncertainty_score":0.4764488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383019259390165,"score_gpt":0.3982020059877211,"score_spread":0.3543718133938195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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