{"id":"W2400927555","doi":"10.1200/jco.2016.66.5844","title":"Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for <i>CH</i><i>EK</i><i>2</i>*1100delC Carriers","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; David Geffen School of Medicine, University of California, Los Angeles; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; Erasmus Universitair Medisch Centrum Rotterdam; Russian Academy of Sciences; Cancer Council South Australia; National Health and Medical Research Council; Medical Research Council; University of California, Los Angeles; U.S. Army; School of Medicine, Stanford University; National Institutes of Health; Universitätsklinikum Köln; Universität zu Köln; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Technische Universität München; Sundhed og Sygdom, Det Frie Forskningsråd; Universitetet i Oslo; Leids Universitair Medisch Centrum; Karolinska Institutet; University of Oxford; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; University of Toronto; Cancer Council NSW; Susan G. Komen for the Cure; Universität Heidelberg; Universiteit van Amsterdam; Cancer Council Victoria; University of Melbourne; London School of Hygiene and Tropical Medicine; Eberhard Karls Universität Tübingen; Universiteit Leiden; Kuopion Yliopistollinen Sairaala; Robert Bosch Stiftung; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Pomorski Uniwersytet Medyczny W Szczecinie; Vrije Universiteit Amsterdam; Agency for Science, Technology and Research; King's College London; National Institute for Health and Care Research; Itä-Suomen Yliopisto; Lon V. Smith Foundation; Stockholms Läns Landsting; KWF Kankerbestrijding; Herlev Hospital; Cancer Research UK; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; University of California, Irvine; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; Cancerfonden; U.S. Department of Health and Human Services; Mayo Clinic; Breast Cancer Research Foundation; Cancer Council Tasmania; Francis Crick Institute; Helsingin Yliopisto","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004136872,0.000525189,0.0004867804,0.001580362,0.0001461692,0.0004743001,0.0005256219,0.000519546,0.001524034],"category_scores_gemma":[0.006856822,0.0002454481,0.001294402,0.0007300917,0.0001633712,0.0003335016,0.0004430719,0.0004252669,0.0003844599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220804,"about_ca_system_score_gemma":0.000191738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00307404,"about_ca_topic_score_gemma":0.002450707,"domain_scores_codex":[0.9986205,0.0005763656,0.0001518283,0.0004266662,0.000171324,0.00005335278],"domain_scores_gemma":[0.996012,0.001662567,0.00141162,0.0005002971,0.0003085608,0.0001049912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004677676,0.00001863449,0.990864,0.00005173964,0.0006997762,0.00006800456,0.00006319902,0.0008582607,0.001109616,0.00005963083,0.0002151503,0.005524347],"study_design_scores_gemma":[0.00005358611,0.0002590829,0.9924757,0.00003285277,0.0009601525,0.0007626057,0.0001224541,0.003168099,0.001092998,0.00025348,0.0008034089,0.00001545822],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900616,0.001544204,0.005348382,0.00005635715,0.000009815171,0.00004129442,0.002129026,0.00007595554,0.0007332795],"genre_scores_gemma":[0.9937163,0.0002947264,0.00323145,0.00002865988,0.00001256033,0.00004331138,0.002402783,0.0000224728,0.0002477631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004136872,"threshold_uncertainty_score":0.02187812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383019259390165,"score_gpt":0.3982020059877211,"score_spread":0.3543718133938195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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